The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review

被引:7
作者
Fioranelli, Massimo [1 ]
Roccia, Maria Grazia [1 ]
Przybylek, Bianca [2 ]
Garo, Maria Luisa [3 ]
机构
[1] Guglielmo Marconi Univ, Dept Human Sci, Via Plinio 44, I-00193 Rome, Italy
[2] Casa Cura Villa Rosario, Ist Terapie Sistem Integrate, Via Flaminia 449, I-00181 Rome, Italy
[3] Casa Cura Sanatrix, Ist Terapie Sistem Integrate, Via Trasone, 6, I-00199 Rome, Italy
来源
LIFE-BASEL | 2023年 / 13卷 / 10期
关键词
BDNF; brain-derived neurotrophic factor; cardiovascular disease; depression; POSTSTROKE DEPRESSION; MYOCARDIAL-INFARCTION; SERUM BDNF; STROKE; METAANALYSES; CONTRACTION; PLASTICITY; DISORDERS; SYMPTOMS; PROTECTS;
D O I
10.3390/life13101967
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Several studies have been conducted to prove the bidirectional relationship between cardiovascular disease (CVD) and depression. These two major illnesses share several common risk factors such that the development of either condition may increase the risk of the occurrence of the other. Brain-derived neurotrophic factor (BDNF) has been suggested as a reliable biomarker for depression and a strong predictor of CVD because it plays an important role in neuron survival and growth, serves as a neurotransmitter modulator, and promotes neuronal plasticity. The aim of this systematic review was to examine the bidirectional relationship between CVD and depression, focusing on the potential role of low serum BDNF levels in the development of either disease in the presence of the other. Methods: A systematic search strategy was developed using PRISMA guidelines. Results: Six studies (comprising 1251 patients) were identified, all of which examined the association between CVD and depression. Conclusions: It was found that there may be a strong association between low serum BDNF levels and the risk of post-stroke depression. However, the studies on the role of altered serum BDNF levels and other types of CVD are few. Therefore, the inverse association between depression and CVD cannot be proven.
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页数:16
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