Consequences of different cut-off values for high-sensitivity cardiac troponin for risk stratification of patients suspected for NSTE-ACS with a modified HEART score

被引：1
作者：
Tolsma, Rudolf T. [1 ]
Fokkert, Marion J. [2 ,3 ]
Ottervanger, Jan Paul [4 ]
van Dongen, Dominique N. [5 ]
Badings, Erik A. [5 ]
van Der Sluis, Aize [5 ]
van't Hof, Arnoud W. J. [6 ,7 ]
Slingerland, Robbert J. [3 ]
机构：
[1] Ambulance IJsselland, Emergency Med Serv, NL-8013 PM Zwolle, Netherlands
[2] Isala, Dept Innovat & Sci, NL-8025 AB Zwolle, Netherlands
[3] Isala, Dept Clin Chem, NL-8025 AB Zwolle, Netherlands
[4] Isala, Dept Cardiol, NL-8025 AB Zwolle, Netherlands
[5] Deventer Hosp, Dept Cardiol, NL-7416 SE Deventer, Netherlands
[6] MUMC, Dept Cardiol, NL-6229 HX Maastricht, Netherlands
[7] Zuyderland MC, Dept Cardiol, NL-6419 PC Heerlen, Netherlands
来源：
FUTURE CARDIOLOGY | 2023年 / 19卷 / 10期
关键词：
acute coronary syndrome; ambulance; biomarkers; EMS; HEART-score; point-of-care; prehospital; risk stratification; triage; troponin; CHEST-PAIN; MYOCARDIAL-INFARCTION; EMERGENCY-DEPARTMENT;
D O I：
10.2217/fca-2023-0038
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: This study aims to enhance prehospital risk assessment for suspected non-ST-elevation acute coronary syndrome (NSTE-ACS) patients using the HEART-score. By incorporating novel point-of-care high-sensitivity cardiac troponin devices, a modified HEART-score was developed and compared with the conventional approach. Patients & methods: Troponin points within the modified HEART-score are based on values below the limit of quantitation (LoQ), between the LoQ and 99th percentile and above the 99th percentile of the used device. A total HEART-score of three or lower is considered low-risk for major adverse cardiac events. Results & conclusion: The number of low-risk patients decreased based on the modified HEART-score. The sensitivity and negative predictive value increased which suggests increasing safety in ruling out patients with suspected NSTE-ACS.
引用
收藏
页码：497 / 504
页数：8
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