Organocatalytic Enantioselective One-pot Synthesis of Dihydrocoumarins via C-H Oxidation and Cyclization Cascade

被引：0

作者：

Kim, Kyeong Seop ^{[1
]}

Kim, Dae Young ^{[1
]}

机构：

[1] Soonchunhyang Univ, Dept Chem, Asan 31538, Chungnam, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

Organocatalysis; One-pot reaction; ortho-Quinone methides; Dihydrocoumarins; Oxazolones; ORTHO-QUINONE METHIDES; FRIEDEL-CRAFTS ALKYLATION; BETA-KETO ACIDS; ASYMMETRIC-SYNTHESIS; MULTICOMPONENT REACTIONS; DECARBOXYLATIVE ALKYLATION; CHIRAL DIHYDROCOUMARINS; CONJUGATE ADDITION; 4+2 CYCLOADDITION; MICHAEL ADDITION;

D O I：

10.1002/ajoc.202300355

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral 3,4-dihydrocoumarin derivatives were obtained from 2-benzyl phenols and oxazolones in moderate to high yields with excellent enantioselectivitie (up to 96 % ee) through one-pot cascade via C-H oxidation and cyclization cascade using a binaphthyl-modified squaramide bifunctional organocatalyst under mild reaction conditions.

引用

页数：4

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