Organocatalytic Enantioselective One-pot Synthesis of Dihydrocoumarins via C-H Oxidation and Cyclization Cascade

被引：0
|
作者：
Kim, Kyeong Seop [1 ]
Kim, Dae Young [1 ]
机构：
[1] Soonchunhyang Univ, Dept Chem, Asan 31538, Chungnam, South Korea
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
Organocatalysis; One-pot reaction; ortho-Quinone methides; Dihydrocoumarins; Oxazolones; ORTHO-QUINONE METHIDES; FRIEDEL-CRAFTS ALKYLATION; BETA-KETO ACIDS; ASYMMETRIC-SYNTHESIS; MULTICOMPONENT REACTIONS; DECARBOXYLATIVE ALKYLATION; CHIRAL DIHYDROCOUMARINS; CONJUGATE ADDITION; 4+2 CYCLOADDITION; MICHAEL ADDITION;
D O I：
10.1002/ajoc.202300355
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral 3,4-dihydrocoumarin derivatives were obtained from 2-benzyl phenols and oxazolones in moderate to high yields with excellent enantioselectivitie (up to 96 % ee) through one-pot cascade via C-H oxidation and cyclization cascade using a binaphthyl-modified squaramide bifunctional organocatalyst under mild reaction conditions.
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页数：4
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