RAB7 GTPases as coordinators of plant endomembrane traffic

被引：0
|
作者：
Rodriguez-Furlan, Cecilia [1 ]
Borna, Rita [1 ]
Betz, Oliver [1 ]
机构：
[1] Washington State Univ, Sch Biol Sci, Pullman, WA 99163 USA
来源：
FRONTIERS IN PLANT SCIENCE | 2023年 / 14卷
关键词：
Rab7; RabG; endosomes; vacuole; tethering; stress; GTPases; PROGRAMMED CELL-DEATH; TETHERING COMPLEXES; GENE SUPERFAMILY; STRESS TOLERANCE; VACUOLE; RETROMER; CONTRIBUTES; AUTOPHAGY; GOLGI; OVEREXPRESSION;
D O I：
10.3389/fpls.2023.1240973
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The ras gene from rat brain (RAB) family of small GTPases is highly conserved among eukaryotes and regulates endomembrane trafficking pathways. RAB7, in particular, has been linked to various processes involved in regulating endocytic and autophagic pathways. Plants have several copies of RAB7 proteins that reflect the intricacy of their endomembrane transport systems. RAB7 activity regulates different pathways of endomembrane trafficking in plants: (1) endocytic traffic to the vacuole; (2) biosynthetic traffic to the vacuole; and (3) recycling from the late endosome to the secretory pathway. During certain developmental and stress related processes another pathway becomes activated (4) autophagic trafficking towards the vacuole that is also regulated by RAB7. RAB7s carry out these functions by interacting with various effector proteins. Current research reveals many unexplored RAB7 functions in connection with stress responses. Thus, this review describes a comprehensive summary of current knowledge of plant RAB7's functions, discusses unresolved challenges, and recommends prospective future research directions.
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页数：9
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