Questions about Using the Induced Membrane Technique to Manage Cases of Congenital Tibial Pseudarthrosis

被引：2
作者：
Klein, Celine [1 ,2 ,3 ]
Gindraux, Florelle [4 ,5 ]
Masquelet, Alain-Charles [6 ]
Mentaverri, Romuald [2 ,4 ,5 ,6 ,7 ]
Gouron, Richard [1 ]
机构：
[1] Amiens Univ Hosp, Jules Verne Univ Picardie, Dept Paediat Orthopaed Surg, F-80054 Amiens, France
[2] Jules Verne Univ Picardie, Amiens Univ, MP3CV EA7517, CURS,Med Ctr, F-80025 Amiens, France
[3] CHU Amiens Picardie, Serv Orthopedie & Traumatol Pediat, F-80054 Amiens 1, France
[4] CHU Besancon, Serv Chirurg Orthoped Traumatol & Plast, F-25000 Besancon, France
[5] Univ Franche Comte, Lab Nanomed, Imagerie, Therapeut EA 4662,LNIT, F-25000 Besancon, France
[6] Sorbonne Univ, Hop St Antoine, F-75006 Paris, France
[7] Jules Verne Univ Picardie, Amiens Univ, Dept Biochem & Endocrine Biol, Med Ctr, F-80025 Amiens, France
来源：
CELLS | 2023年 / 12卷 / 14期
关键词：
induced membrane; congenital pseudarthrosis of the tibia; neurofibromatosis; 1; Masquelet's technique; leg; children; BONE MORPHOGENETIC PROTEIN; FIBROUS HAMARTOMA; FRACTURE REPAIR; RECONSTRUCTION; DIFFERENTIATION; RESECTION; CHILDREN; NF1; PERIOSTEUM; PATHOLOGY;
D O I：
10.3390/cells12141918
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The induced membrane technique is an innovative approach for repairing critical bone defects and has been applied recently in patients with congenital pseudarthrosis of the tibia (CPT). CPT is frequently associated with neurofibromatosis type 1 (NF1). Here, we briefly describe the clinical results of the induced membrane technique in NF1-deficient patients with CPT and in an animal model of CPT. Furthermore, we discuss the hypotheses used to explain inconsistent outcomes for the induced membrane technique in CPT-especially when associated with NF1.
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页数：6
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