Polysaccharides from Oudemansiella radicata residues attenuate carbon tetrachloride-induced liver injury

被引：5

作者：

Wang, Wenshuai ^{[1
]}

Zhang, Yaohan ^{[1
]}

Liu, Xinchao ^{[1
]}

Liu, Zonghui ^{[2
]}

Jia, Le ^{[1
]}

Zhang, Jianjun ^{[1
]}

机构：

[1] Shandong Agr Univ, Coll Life Sci, Tai An 271018, Peoples R China

[2] Taian Maternal & Child Hlth Care Hosp, Tai An 271000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 242卷

关键词：

Hepatoprotection Oudemansiella radicata Residue polysaccharides; ANTIOXIDANT ACTIVITY; ANTITUMOR-ACTIVITY; GANODERMA-LUCIDUM; OXIDATIVE STRESS; IN-VITRO; PURIFICATION; MECHANISMS; FIBROSIS; BIOACTIVITIES; INFLAMMATION;

D O I：

10.1016/j.ijbiomac.2023.124823

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present work aimed to investigate the potential hepatoprotective effects of Oudemansiella radicata residues polysaccharides (RPS). Our results demonstrated that RPS showed significantly protective effects against carbon tetrachloride (CCl4)-induced liver injury, and the possible mechanisms may be related with the predominant bioactivities of RPS containing anti-oxidation by activating the Nrf2 signal pathways, anti-inflammation by inhibiting NF-kappa B signal pathways and reducing the release of inflammatory cytokines, anti-apoptosis by regulating Bcl-2/Bax pathway, and anti-fibrosis by inhibiting the expressions of TGF-beta 1, Hyp and alpha-SMA, respectively. These findings suggested that RPS, a typical beta-type glycosidic pyranose, could be used as a promising diet supplement or medication for the adjunctive treatment of hepatic diseases, and also contributed to promoting the recyclable utilization of mushroom residues.

引用

页数：11

共 49 条

[1] Reactive oxygen species and superoxide dismutases: Role in joint diseases [J].

Afonso, Valery ;

Champy, Rornuald ;

Mitrovic, Dragoslav ;

Collin, Pascal ;

Lomri, Abderrahim .

JOINT BONE SPINE, 2007, 74 (04) :324-329

[2] Protective effect of Diyarbakir watermelon juice on carbon tetrachloride-induced toxicity in rats [J].

Altas, Sevcan ;

Kizil, Goksel ;

Kizil, Murat ;

Ketani, Aydin ;

Haris, Parvez I. .

FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (09) :2433-2438

[3] Zizyphus spina-christi protects against carbon tetrachloride-induced liver fibrosis in rats [J].

Amin, Amr ;

Mahmoud-Ghoneim, Doaa .

FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (08) :2111-2119

[4] New insights into the mechanisms controlling neutrophil survival [J].

Cabrini, Mercedes ;

Nahmod, Karen ;

Geffner, Jorge .

CURRENT OPINION IN HEMATOLOGY, 2010, 17 (01) :31-35

[5] Mechanism of cadmium induced apoptosis in the immunocyte [J].

Chatterjee, Sountya ;

Kundu, Subhadip ;

Bhattacharyya, Arindam .

TOXICOLOGY LETTERS, 2008, 177 (02) :83-89

[6] Naringin prevents carbon tetrachloride-induced acute liver injury in mice [J].

Dong, Deshi ;

Xu, Lina ;

Yin, Lianhong ;

Qi, Yan ;

Peng, Jinyong .

JOURNAL OF FUNCTIONAL FOODS, 2015, 12 :179-191

[7] Esomeprazole ameliorates CCl4 induced liver fibrosis in rats via modulating oxidative stress, inflammatory, fibrogenic and apoptotic markers [J].

Eltahir, Heba M. ;

Nazmy, Maiiada H. .

BIOMEDICINE & PHARMACOTHERAPY, 2018, 97 :1356-1365

[8] Formation and removal of reactive oxygen species, lipid peroxides and free radicals, and their biological effects [J].

Fujita, T .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2002, 122 (03) :203-218

[9] Production, preliminary characterization and antitumor activity in vitro of polysaccharides from the mycelium of Pholiota dinghuensis Bi [J].

Gan, Dan ;

Ma, Liping ;

Jiang, Changxing ;

Xu, Renjie ;

Zeng, Xiaoxiong .

CARBOHYDRATE POLYMERS, 2011, 84 (03) :997-1003

[10]

Gao Z., CARBOHYD POLYM, V204, P2018

← 1 2 3 4 5 →