Synthetic Utility of the Vilsmeier-Haack Reagent in Organic Synthesis

被引：2

作者：

Neena, Neena ^{[1
]}

Chaudhri, Vishwas ^{[2
]}

Singh, Fateh V. V. ^{[3
]}

China, Hideyasu ^{[4
]}

Dohi, Toshifumi ^{[5
]}

Kumar, Ravi ^{[1
,2
]}

机构：

[1] Dyal Singh Coll, Dept Chem, Karnal 132001, India

[2] Dept Chem, JC Bose Univ Sci & Technol, YMCA, NH-2,Mathura Rd, Faridabad 121006, India

[3] Vellore Inst Technol VIT Chennai, Sch Adv Sci, Chem Div, Vandalur Kelambakkam Rd, Chennai 600127, Tamil Nadu, India

[4] Nagahama Inst Biosci & Technolog, Dept Med Biosci, 1266,Tamuracho, Nagahama, Shiga 5260829, Japan

[5] Ritsumeikan Univ, Grad Sch Pharmaceut Sci, 1-1-1 Nojihigashi, Kusatsu, Shiga 5258577, Japan

来源：

SYNLETT | 2023年 / 34卷 / 07期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

Vilsmeier-Haack reagent; formylation; chlorination; heterocycles; MICROWAVE-ASSISTED SYNTHESIS; SIMPLE ROUTE; EFFICIENT; DERIVATIVES; FACILE; ACID; MACKINAZOLINONE; FORMYLATION; CYCLIZATION; CONVENIENT;

D O I：

10.1055/s-0042-1751421

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Vilsmeier-Haack reaction has historically been a topic of significant interest to organic chemists, and it continues to attract considerable attention. The reaction itself provides a facile route towards a large number of aromatic and heteroaromatic systems. The Vilsmeier-Haack reagent, generated from amides and halides, is found to be very important in organic synthesis. This account highlights recent developments in the synthetic utility of the Vilsmeier-Haack reagent. 1 Introduction 2 Formylation 3 Formylation and Chlorination 4 Formylation and Acetylation 5 Chlorination 6 ortho-Formylation 7 Miscellaneous 8 Conclusions

引用

页码：777 / 792

页数：16

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