An l-arginine-functionalized pillar[5]arene-based supramolecular photosensitizer for synergistically enhanced cancer therapeutic effectiveness

被引：12
作者：
Chao, Shuang [1 ,2 ]
Shen, Ziyan [1 ]
Li, Bowen [1 ]
Pei, Yuxin [1 ]
Pei, Zhichao [1 ,2 ]
机构：
[1] Northwest A&F Univ, Coll Chem & Pharm, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Peoples R China
[2] Northwest A&F Univ, Coll Plant Protect, Yangling 712100, Shaanxi, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 23期
关键词：
Arginine - Aromatic hydrocarbons - Cancer cells - Cells - Cytology - Diseases - Micelles - Positive ions - Supramolecular chemistry;
D O I：
10.1039/d3cc00123g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An l-arginine-functionalized pillar[5]arene-based supramolecular photosensitizer LAP5 superset of NBSPD was constructed by host-guest interactions, which could self-assemble into nano-micelles to achieve effective delivery and selective release of LAP5 and NBS in cancer cells. In vitro studies revealed that LAP5 superset of NBSPD NPs exhibited excellent cancer cell membrane disruption and ROS generation properties, which provides a novel route for synergistically enhanced cancer therapeutic effectiveness.
引用
收藏
页码：3455 / 3458
页数：4
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