Organ-On-A-Chip: An Emerging Research Platform

被引：20

作者：

Nithin, R. ^{[1
]}

Aggarwal, Ayushi ^{[1
]}

Sravani, Anne Boyina ^{[1
]}

Mallya, Pooja ^{[1
]}

Lewis, Shaila ^{[1
,2
]}

机构：

[1] Manipal Acad Higher Educ MAHE, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Manipal, Karnataka, India

[2] Manipal Acad Higher Educ MAHE, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Manipal 576104, Karnataka, India

来源：

ORGANOGENESIS | 2023年 / 19卷 / 01期

关键词：

Drug interactions; drug testing; human biology; organ-on-a-chip; toxicity; CELL-CULTURE ANALOG; IN-VITRO MODEL; MICROFLUIDIC MODEL; DRUG; METABOLISM; KIDNEY; STIMULATION; BIOREACTOR; ABSORPTION; DEVICES;

D O I：

10.1080/15476278.2023.2278236

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology. To overcome this limitation, the emergence of organ-on-a-chip (OOC) technology has sparked interest as a transformative approach in drug testing research. By closely replicating human organ responses to external signals, OOC devices hold immense potential in revolutionizing drug efficacy and safety predictions. This review focuses on the advancements, applications, and prospects of OOC devices in drug testing. Based on the latest advances in the field of OOC systems and their clinical applications, this review reflects the effectiveness of OOC devices in replacing human volunteers in certain clinical studies. This review underscores the critical role of OOC technology in transforming drug testing methodologies.

引用

页数：19

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