Thermoneutral housing does not rescue olanzapine-induced trabecular bone loss in C57BL/6J female mice

被引:1
|
作者
Langlais, Audrie L. [1 ,2 ]
Mountain, Rebecca V. [1 ]
Kunst, Roni F. [1 ]
Barlow, Deborah [3 ]
Houseknecht, Karen L. [2 ,3 ]
Motyl, Katherine J. [1 ,2 ,4 ,5 ]
机构
[1] MaineHealth, MaineHlth Inst Res, Ctr Mol Med, Scarborough, ME USA
[2] Univ Maine, Grad Sch Biomed Sci & Engn, Orono, ME USA
[3] Univ New England, Coll Osteopath Med, Dept Biomed Sci, Biddeford, ME USA
[4] Tufts Univ, Sch Med, Boston, MA USA
[5] 81 Res Dr, Scarborough, ME 04074 USA
关键词
Antipsychotic drugs; Bone; Thermoneutrality; Sympathetic nervous system; ATYPICAL ANTIPSYCHOTIC-DRUGS; MINERAL DENSITY; LOCOMOTOR-ACTIVITY; WEIGHT-GAIN; RISPERIDONE; RISK; FRACTURE; THERMOGENESIS; CONSEQUENCES; OSTEOPOROSIS;
D O I
10.1016/j.biochi.2023.05.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Antipsychotic drugs are prescribed to a wide range of individuals to treat mental health conditions including schizophrenia. However, antipsychotic drugs cause bone loss and increase fracture risk. We previously found that the atypical antipsychotic (AA) drug risperidone causes bone loss through multiple pharmacological mechanisms, including activation of the sympathetic nervous system in mice treated with clinically relevant doses. However, bone loss was dependent upon housing temperature, which modulates sympathetic activity. Another AA drug, olanzapine, has substantial metabolic side effects, including weight gain and insulin resistance, but it is unknown whether bone and metabolic outcomes of olanzapine are also dependent upon housing temperature in mice. We therefore treated eight week-old female mice with vehicle or olanzapine for four weeks, housed at either room temperature (23 & DEG;C) or thermoneutrality (28-30 & DEG;C), which has previously been shown to be positive for bone. Olanzapine caused significant trabecular bone loss (-13% BV/TV), likely through increased RANKL-dependent osteoclast resorption, which was not suppressed by thermoneutral housing. Additionally, olanzapine inhibited cortical bone expansion at thermoneutrality, but did not alter cortical bone expansion at room temperature. Olanzapine also increased markers of thermogenesis within brown and inguinal adipose depots independent of housing temperature. Overall, olanzapine causes trabecular bone loss and inhibits the positive effect of thermoneutral housing on bone. Understanding how housing temperature modulates the impact of AA drugs on bone is important for future pre-clinical studies, as well as for the prescription of AA drugs, particularly to older adults and adolescents who are most vulnerable to the effects on bone.& COPY; 2023 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
引用
收藏
页码:50 / 60
页数:11
相关论文
共 50 条
  • [31] Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice
    Hou, Po-Hsun
    Chang, Geng-Ruei
    Chen, Chin-Pin
    Lin, Yen-Ling
    Chao, I-Shuan
    Shen, Ting-Ting
    Mao, Frank Chiahung
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2018, 21 (05) : 495 - 501
  • [32] Effects of volumetric muscle loss injury on contractile function, and bone structure and functional capacity in male C57BL/6J mice
    Schifino, Albino
    Cooley, Marion
    Zhong, Roger
    Heo, Junwon
    Hoffman, Daniel
    Warren, Gordon
    Greising, Sarah
    Call, Jarrod
    PHYSIOLOGY, 2023, 38
  • [33] Developmental vitamin D deficiency alters learning in C57Bl/6J mice
    de Abreu, Diana Andrea Fernandes
    Nivet, Emmanuel
    Baril, Nathalie
    Khrestchatisky, Michel
    Roman, Francois
    Feron, Francois
    BEHAVIOURAL BRAIN RESEARCH, 2010, 208 (02) : 603 - 608
  • [34] CALCIUM, IRON, COPPER, BORON, COLLAGEN, AND DENSITY CHANGES IN BONE WITH AGING IN C57BL/6J MALE-MICE
    MASSIE, HR
    AIELLO, VR
    SHUMWAY, ME
    ARMSTRONG, T
    EXPERIMENTAL GERONTOLOGY, 1990, 25 (05) : 469 - 481
  • [35] The Effects of Breeding Protocol in C57BL/6J Mice on Adult Offspring Behaviour
    Foldi, Claire J.
    Eyles, Darryl W.
    McGrath, John J.
    Burne, Thomas H. J.
    PLOS ONE, 2011, 6 (03):
  • [36] Intravenous cocaine-induced activity in A/J and C57BL/6J mice: behavioral sensitization and conditioned activity
    Mead, AN
    Katz, JL
    Rocha, BA
    NEUROPHARMACOLOGY, 2002, 42 (07) : 976 - 986
  • [37] Prepubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice
    Govoni, Kristen E.
    Wergedal, Jon E.
    Chadwick, Robert B.
    Srivastava, Apurva K.
    Mohan, Subburaman
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 295 (05): : E1172 - E1180
  • [38] Effects of fermented barley on lipid and carnitine profiles in C57BL/6J mice
    Choi, Ji-Hae
    Kim, Tae-Hee
    Ko, Myung-Suk
    Cha, Youn-Soo
    FOOD SCIENCE AND BIOTECHNOLOGY, 2012, 21 (02) : 323 - 329
  • [39] Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
    Elbaz, Alexander
    Rivas, Daniel
    Duque, Gustavo
    BIOGERONTOLOGY, 2009, 10 (06) : 747 - 755
  • [40] Propranolol Promotes Bone Formation and Limits Resorption Through Novel Mechanisms During Anabolic Parathyroid Hormone Treatment in Female C57BL/6J Mice
    Treyball, Annika
    Bergeron, Audrey C.
    Brooks, Daniel J.
    Langlais, Audrie L.
    Hashmi, Hina
    Nagano, Kenichi
    Barlow, Deborah
    Neilson, Ryan J.
    Roy, Tyler A.
    Nevola, Kathleen T.
    Houseknecht, Karen L.
    Baron, Roland
    Bouxsein, Mary L.
    Guntur, Anyonya R.
    Motyl, Katherine J.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2022, 37 (05) : 954 - 971