The predictive markers of severity and mortality in hospitalized hemodialysis patients with COVID-19 during Omicron epidemic

被引：3

作者：

Banshodani, Masataka ^{[1
,3
]}

Kawanishi, Hideki ^{[1
]}

Hirai, Takayuki ^{[2
]}

Kawai, Yusuke ^{[1
]}

Hashimoto, Shinji ^{[1
]}

Shintaku, Sadanori ^{[1
]}

Moriishi, Misaki ^{[1
]}

Marubayashi, Seiji ^{[2
]}

Tsuchiya, Shinichiro ^{[1
]}

机构：

[1] Tsuchiya Gen Hosp, Akane Fdn, Kidney Dis & Blood Purificat Therapy, Hiroshima, Japan

[2] Ajina Tsuchiya Hosp, Akane Fdn, Kidney Dis & Dialysis, Hatsukaichi, Japan

[3] Tsuchiya Gen Hosp, Akane Fdn, Kidney Dis & Blood Purificat Therapy, 3-30 Nakajimacho,Naka ku, Hiroshima 7308655, Japan

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2023年 / 27卷 / 04期

关键词：

CCL17; COVID-19; hemodialysis; Omicron variant; SARS-CoV-2; SARS-COV-2; OMICRON; CHEMOKINE; OUTCOMES; THYMUS;

D O I：

10.1111/1744-9987.13970

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Predictive markers and prognosis remain unclear in hospitalized hemodialysis (HD) patients with coronavirus disease 2019 (COVID-19) during the Omicron epidemic.Methods: We evaluated characteristics, laboratory parameters, and outcomes in hospitalized HD patients with COVID-19 (n = 102) at two centers between January and April 2022.Results: The 30-day mortality rate was higher in moderate-critical group (n = 43) than mild group (n = 59) (16.3% vs. 1.7%; p = 0.007), and higher in patients with lower C C chemokine ligand 17 (CCL17) levels (< 95.0 pg/mL) compared with normal CCL17 levels (19.0% versus 4.9%; p = 0.03). In multivariate analyses, a low CCL17 level (p = 0.003) was associated with moderate-critical conditions, and moderate-critical conditions (p = 0.04) were associated with 30-day mortality, whereas CCL17 was not associated with 30-day mortality.Conclusions: COVID-19 remains a fatal complication, and CCL17 was a predictive marker of severity in hospitalized HD patients during the Omicron epidemic.

引用

页码：701 / 710

页数：10

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