Photosensitizers with aggregation-induced far-red/near-infrared emission for versatile visualization and broad-spectrum photodynamic killing of pathogenic microbes

被引：14

作者：

Luo, Jiabao ^{[1
,3
]}

Yang, Ping ^{[2
]}

Cheng, Jingxi ^{[3
]}

Fan, Jiaqi ^{[1
]}

Zhou, Weiying ^{[1
]}

Lu, Yaru ^{[3
]}

Xie, XiaoBao ^{[1
,2
]}

Wu, Wenbo ^{[3
]}

Zhang, Xinguo ^{[1
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, NMPA Key Lab Res & Evaluat Drug Metab, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China

[2] Guangdong Acad Sci, Guangdong Detect Ctr Microbiol, Guangdong Prov Key Lab Microbial Culture Collect &, State Key Lab Appl Microbiol Southern China,Inst M, Guangzhou 510070, Peoples R China

[3] Tianjin Univ, Inst Mol Aggregat Sci, Dept Chem, Tianjin 300072, Peoples R China

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2023年 / 634卷

关键词：

Visualization; Broad-spectrum; Antimicrobial; Aggregation-induced emission; Photodynamic killing; Drug-resistance; DISCRIMINATION; THERANOSTICS;

D O I：

10.1016/j.jcis.2022.12.062

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The exploration of photosensitizers with aggregation-induced emission (AIE PSs) for efficient visualization and broad-spectrum photodynamic killing of pathogenic microbes is a significant task. Herein, two far-red/near-infrared AIE-active PSs (TBTPy and TBTCy) were attained to show efficient Type I and Type II ROS generation, benefiting from the efficient ISC processes. The attained AIE PSs, especially TBTPy with bright emission, showed advantages in discriminating G+ bacteria over G- bacteria, and distinguishing dead E. coli from lived one. Both TBTPy and TBTCy have the capacity of broad-spectrum photodynamic killing of pathogenic microbes in vitro with considerable safety for mammalian cells. Antimicrobial mechanism is found to be changing osmotic pressure of cytoplasm in E. coli, causing cell deformation and destruction of S. aureus and C. albicans. In vivo anti-infection experiment demonstrated AIE PSs can accelerate the healing process of the burned wounds on rats infected by methicillin-resistant S. aureus (MRSA) or E. coli, indicating their potential to treat tertiary burns in clinical application. Therefore, the attained AIE PSs hold great promise as antimicrobial candidates in infective therapeutic application.(c) 2022 Elsevier Inc. All rights reserved.

引用

页码：664 / 674

页数：11

共 43 条

[1] Combined tetraphenylethylene fluorogens with positive charge for imaging capsule-covered pathogens [J].