New coumarin glycosides from endemic Prangos heyniae H. Duman & MF Watson

被引：14

作者：

Albayrak, Gokay ^{[1
,2
]}

Demir, Serdar ^{[2
]}

Kose, Fadime Aydin ^{[3
]}

Baykan, Sura ^{[2
]}

机构：

[1] Izmir Katip Celebi Univ, Fac Pharm, Dept Pharmaceut Bot, Izmir, Turkey

[2] Ege Univ, Dept Pharmaceut Bot, Fac Pharm, Izmir, Turkey

[3] Izmir Katip Celebi Univ, Fac Pharm, Dept Biochem, Izmir, Turkey

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 02期

关键词：

Prangos; Apiaceae; coumarin; cytotoxicity; ANTIOXIDANT ACTIVITIES; ESSENTIAL OIL; CONSTITUENTS; PLANT; FURANOCOUMARIN; APIACEAE; FRUITS; IDENTIFICATION; DERIVATIVES; ANATOLIA;

D O I：

10.1080/14786419.2021.1961138

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new coumarin glycosides, named 7-methoxy isoarnottinin 4'-O-beta-D-glucopyranoside and 7-methoxy isoarnottinin 4'-O-rutinoside (1 and 2) along with six known compounds (3-8) were isolated from the roots of Prangos heyniae, an endemic plant of Turkey. 1-methylethyl 6-O-D-apio-beta-D-furanosyl-beta-D-glucopyranoside (7) and cnidioside A (8) have been obtained from the genus Prangos for the first time. Structures of isolated compounds were established using spectroscopic methods (1D and 2D NMR, HR-MS, UV and IR). Moreover, all extracts and isolated compounds were evaluated for their cytotoxic activity against NIH/3T3, HK-2, A-549, MCF-7, PC-3 and SH-SY5Y cell lines by WST-1 method. One of the new coumarin glycosides, 7-methoxy isoarnottinin 4'-O-beta-D-glucopyranoside (1) exhibited selective cytotoxic activity against SH-SY5Y cells with IC50 value of 31.41 +/- 1.04 mu M. [GRAPHICS]

引用

页码：227 / 239

页数：13

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