ALK Rearrangement Positive Lung Adenocarcinoma in Pregnancy Treated With Alectinib: A Case Report

被引：1

作者：

Gonzalez-Mosquera, Luis F. ^{[1
]}

Abu Rous, Fawzi ^{[1
]}

Rogers, Alexandra ^{[2
]}

Smith, Nicolina ^{[3
]}

Goyert, Gregory ^{[3
]}

Gadgeel, Shirish ^{[1
,4
]}

机构：

[1] Henry Ford Hlth, Henry Ford Canc Inst, Div Hematol & Oncol, Dept Internal Med, Detroit, MI USA

[2] Wayne State Univ, Sch Med, Detroit, MI USA

[3] Henry Ford Hlth, Dept Obstet & Gynecol, Div Maternal & Fetal Med, Detroit, MI USA

[4] Henry Ford Hlth, Henry Ford Canc Inst, Dept Internal Med, Div Hematol Oncol, 2800 West Grand Blvd, Detroit, MI 48202 USA

来源：

CLINICAL LUNG CANCER | 2024年 / 25卷 / 02期

关键词：

Adenocarcinoma; Alectinib; Anaplastic lymphoma kinase; Metastatic lung cancer; Pregnancy; CANCER; FEATURES; NSCLC;

D O I：

10.1016/j.cllc.2023.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There are few reported cases of ALK gene rearranged (ALK + ) non-small cell lung cancer (NSCLC) during pregnancy. There is a lack of information on the safety of ALK inhibitors in pregnant patients. We present a 25-year-old African American woman who was diagnosed with metastatic ALK + lung adenocarcinoma at 15 weeks of gestation. Treatment with alectinib was initiated at 18 weeks' gestation with resultant radiological treatment response. The patient did not experience any adverse effects from alectinib during her pregnancy. An elective induction of labor at 39 weeks resulted in an uncomplicated vaginal delivery. This case adds to available data and provides insight on the safety of using alectinib in a pregnant, ALK + NSCLC patient, allowing the patient to continue her pregnancy to term while treating advanced lung adenocarcinoma.

引用

页码：e77 / e80

页数：4

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