Primary Autologous Stem Cell Transplantation for Unilateral Primary Central Nervous System Lymphoma-Ophthalmic Variant (Primary Vitreoretinal Lymphoma)

被引：2

作者：

Lee, Brian ^{[1
]}

de Vos, Sven ^{[2
]}

Mccannel, Colin A. ^{[3
,4
]}

机构：

[1] Univ Calif Los Angeles, Stein Eye & Doheny Eye Inst, Dept Ophthalmol, Los Angeles, CA USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol & Oncol, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Stein Eye Inst, Dept Ophthalmol, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Stein Eye Inst, Dept Ophthalmol, 200 Stein Plaza, Los Angeles, CA 90095 USA

来源：

JOURNAL OF VITREORETINAL DISEASES | 2023年 / 7卷 / 06期

关键词：

primary vitreoretinal lymphoma; primary central nervous system lymphoma; autologous stem cell transplantation; primary central nervous system lymphoma-ophthalmic variant; HIGH-DOSE METHOTREXATE; INTRAOCULAR LYMPHOMA; PRIMARY CNS;

D O I：

10.1177/24741264231174094

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To describe the long-term outcomes of 2 cases of primary autologous stem cell transplantation (ASCT) for the treatment of primary central nervous system lymphoma-ophthalmic variant (PCNSL-O) or primary vitreoretinal lymphoma (PVRL). Methods: Two cases and their findings were analyzed. A review of the histopathology, systemic treatment, and multimodal ocular imaging was performed. Results: A 52-year-old woman and 56-year-old woman were referred for vitritis and retinal lesions suspicious for PCNSL-O. The initial vitreous biopsies were inconclusive. Both patients had subsequent chorioretinal biopsies that confirmed the diagnosis of diffuse large B-cell lymphoma. No systemic or central nervous system involvement was found on systemic workup. Both patients received intravitreal and systemic chemotherapy followed by ASCT, and both remained in complete remission 7 and 8 years later. Conclusions: These cases show the long-term survival of patients diagnosed with PVRL when primary ASCT, the primary treatment for PCNSL, is performed.

引用

页码：548 / 551

页数：4

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