Fibrinolytic drugs induced hemorrhage: mechanisms and solutions

被引：3

作者：

Tang, Mingqing ^{[1
]}

Hu, Chengjia ^{[1
]}

Lin, Hongjun ^{[1
]}

Yan, Hui ^{[1
]}

机构：

[1] Huaqiao Univ, Med Sch, Quanzhou 362021, Fujian, Peoples R China

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2023年 / 34卷 / 05期

关键词：

fibrinolytic drug; hemorrhage; metalloproteinase; serine proteases; thrombolytic drug; SNAKE-VENOM METALLOPROTEINASE; VON-WILLEBRAND-FACTOR; PLASMINOGEN-ACTIVATOR; CRYSTAL-STRUCTURE; MATRIX PROTEINS; DOMAIN; COAGULATION; THROMBOSIS; APOPTOSIS; CLEAVAGE;

D O I：

10.1097/MBC.0000000000001231

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombosis has been emerging as a major global life-threatening issue with high mortality and serious complications, especially in the post-COVID-19 era. Compared with the commonly used plasminogen activators thrombolytic drugs, fibrinolytic drugs are no longer heavily dependent on the patients' own plasminogen, which are poorly expressed in most patients. As a novel "direct acting" thrombolytic agent, fibrinolytic drugs are considered to have stronger thrombolytic efficacy and safety than the widely used plasminogen activators. However, the risk of their hemorrhage remains a major concern. Herein, the molecular mechanisms and solutions were summarized for the first time based on the systematic review of the latest developments, which could shed new light on the development of novel safety fibrinolytic drugs in the future.

引用

页码：263 / 271

页数：9

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