Heterotypic signaling of cancer-associated fibroblasts in shaping the cancer cell drug resistance

被引：9

作者：

Butti, Ramesh ^{[1
,4
]}

Khaladkar, Ashwini ^{[2
]}

Bhardwaj, Priya ^{[3
]}

Prakasam, Gopinath ^{[1
]}

机构：

[1] Univ Texas, Simmons Comprehens Canc Ctr, Kidney Canc Program, Southwestern Med Ctr, Dallas, TX USA

[2] Indian Inst Technol, Dept Biosci & Bioengn, Mumbai 400076, India

[3] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India

[4] Univ Texas, Simmons Comprehens Canc Ctr, Kidney Canc Program, Southwestern Med Ctr, Forest Pk Rd, Dallas, TX 75235 USA

来源：

CANCER DRUG RESISTANCE | 2023年 / 6卷 / 01期

关键词：

Tumor microenvironment; CAFs; heterogeneity; ECM; metabolic reprogramming; heterotypic signaling; drug resistance; natural products; CARCINOMA-ASSOCIATED-FIBROBLASTS; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR MICROENVIRONMENT; BREAST-CANCER; PANCREATIC-CANCER; STEM-CELLS; COLORECTAL-CANCER; TGF-BETA; PATHOLOGICAL FUNCTIONS; TAMOXIFEN RESISTANCE;

D O I：

10.20517/cdr.2022.72

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The context-dependent reciprocal interaction between the cancer cells and surrounding fibroblasts is imperative for regulating malignant potential, metabolic reprogramming, immunosuppression, and ECM deposition. However, recent evidence also suggests that cancer-associated fibroblasts induce chemoresistance in cancer cells to various anticancer regimens. Because of the protumorigenic function of cancer-associated fibroblasts, these stromal cell types have emerged as fascinating therapeutic targets for cancer. However, this notion was recently challenged by studies that targeted cancer-associated fibroblasts and highlighted the underlying heterogeneity by identifying a subset of these cells with tumor-restricting functions. Hence, it is imperative to understand the heterogeneity and heterotypic signaling of cancer-associated fibroblasts to target tumor-promoting signaling processes by sparing tumor-restricting ones. In this review, we discuss the heterogeneity and heterotypic signaling of cancer-associated fibroblasts in shaping drug resistance and also list the cancer-associated fibroblast-targeting therapeutics.

引用

页码：182 / 204

页数：23

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