Senotherapeutics for mesenchymal stem cell senescence and rejuvenation

被引：7
作者：
Wong, Pooi-Fong [1 ]
Dharmani, Murugan [1 ]
Ramasamy, Thamil Selvee [2 ]
机构：
[1] Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Fac Med, Dept Mol Med, Stem Cell Biol Lab, Kuala Lumpur 50603, Malaysia
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 01期
关键词：
cellular senescence; rejuvenation; senolytics; senomorphics; stem cell therapy; MARROW STROMAL CELLS; AGE-RELATED-CHANGES; OSTEOGENIC DIFFERENTIATION; REGENERATIVE MEDICINE; SECRETORY PHENOTYPE; OXIDATIVE STRESS; AGING MECHANISMS; GENE-EXPRESSION; LIFE-SPAN; INHIBITION;
D O I：
10.1016/j.drudis.2022.103424
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mesenchymal stem cells (MSCs) are susceptible to replicative senescence and senescence-associated functional decline, which hampers their use in regenerative medicine. Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence-associated secreted phenotype (SASP), respectively. Therefore, senotherapeutics could delay aging-associated degeneration. They could also be used to eliminate senescent MSCs during in vitro expansion or bioprocessing for transplantation. In this review, we discuss the role of senotherapeutics in MSC senescence, rejuvenation, and transplan-tation, with examples of some tested compounds in vitro. The prospects, challenges, and the way forward in clinical applications of senotherapeutics in cell-based therapeutics are also discussed.
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页数：14
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