The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial

被引：7

作者：

Gardener, Samantha L. ^{[1
,2
,3
]}

Fuller, Stephanie J. ^{[4
]}

Naismith, Sharon L. ^{[5
]}

Baker, Laura ^{[6
]}

Kivipelto, Miia ^{[7
,8
]}

Villemagne, Victor L. ^{[1
,9
,10
]}

Grieve, Stuart M. ^{[11
]}

Yates, Paul ^{[10
]}

Rainey-Smith, Stephanie R. ^{[1
,2
,3
,12
,13
]}

Chen, Juliana ^{[4
,14
]}

Thompson, Belinda ^{[15
]}

Armstrong, Nicola J. ^{[16
]}

Fernando, Malika G. ^{[4
]}

Castro, Carolina Blagojevic ^{[2
,13
]}

Meghwar, Silochna ^{[4
]}

Raman, Rema ^{[17
]}

Gleason, Andrew ^{[4
,18
,19
]}

Ireland, Catriona ^{[5
]}

Clarnette, Roger ^{[12
]}

Anstey, Kaarin J. ^{[20
]}

Taddei, Kevin ^{[1
]}

Garg, Manohar ^{[4
]}

Sohrabi, Hamid R. ^{[1
,2
,4
,13
]}

Martins, Ralph N. ^{[1
,2
,4
,13
]}

机构：

[1] Edith Cowan Univ, Ctr Excellence Alzheimers Dis Res & Care, Sch Med & Hlth Sci, Joondalup, WA, Australia

[2] Ralph & Patricia Sarich Neurosci Res Inst, Alzheimers Res Australia, Nedlands, WA, Australia

[3] Murdoch Univ, Lifestyle Approaches Cognit Hlth Res Grp, Murdoch, WA, Australia

[4] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia

[5] Univ Sydney, Sydney, NSW, Australia

[6] Wake Forest Univ, Sch Med, Winston Salem, NC USA

[7] Karolinska Inst, Solna, Stockholm, Sweden

[8] FINGERS Brain Hlth Inst, Stockholm, Sweden

[9] Univ Pittsburgh, Pittsburgh, PA USA

[10] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia

[11] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Imaging & Phenotyping Lab, Sydney, NSW, Australia

[12] Univ Western Australia, Perth, WA, Australia

[13] Murdoch Univ, Ctr Hlth Ageing, Murdoch, WA, Australia

[14] Univ Sydney, Charles Perkins Ctr, Susan Wakil Sch Nursing & Midwifery, Discipline Nutr & Dietet, Sydney, NSW, Australia

[15] Macquarie Univ, Dept Hlth Sci, Australian Lymphoedema Educ Res & Treatment, Sydney, NSW, Australia

[16] Curtin Univ, Bentley, WA, Australia

[17] Univ Southern Calif, Alzheimers Therapeut Res Inst, San Diego, CA USA

[18] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[19] Monash Univ, Alfred Ctr, Cent Clin Sch, Dept Neurosci, Melbourne, Vic, Australia

[20] Univ New South Wales, Sydney, NSW, Australia

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2024年 / 10卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Alzheimer's disease; Australia; brain health; dementia; multidomain lifestyle intervention; randomized controlled trial; study protocol; EXERCISE; BIOMARKERS; ADULTS; DIET;

D O I：

10.1002/trc2.12466

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: The Finnish Geriatric Intervention Study (FINGER) led to the global dementia risk reduction initiative: World-Wide FINGERS (WW-FINGERS). As part of WW-FINGERS, the Australian AU-ARROW study mirrors aspects of FINGER, as well as US-POINTER. METHOD: AU-ARROW is a randomized, single-blind, multisite, 2-year clinical trial (n = 600; aged 55-79). The multimodal lifestyle intervention group will engage in aerobic exercise, resistance training and stretching, dietary advice to encourage MIND diet adherence, BrainHQ cognitive training, and medical monitoring and health education. The Health Education and Coaching group will receive occasional health education sessions. The primary outcome measure is the change in a global composite cognitive score. Extra value will emanate from blood biomarker analysis, positron emission tomography (PET) imaging, brain magnetic resonance imaging (MRI), and retinal biomarker tests. DISCUSSION: The finalized AU-ARROW protocol is expected to allow development of an evidence-based innovative treatment plan to reduce cognitive decline and dementia risk, and effective transfer of research outcomes into Australian health policy.

引用

页数：20

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