Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report

被引：1

作者：

Jung, Regina ^{[1
]}

Ly, Kevin ^{[2
]}

Taniguchi, Michiko ^{[3
,4
]}

Arriola, Aileen Grace ^{[3
,4
]}

Gravante, Christopher ^{[3
]}

Shinn, Derek ^{[3
]}

Mathew, Leena ^{[3
]}

Hamad, Eman ^{[5
]}

Geier, Steven ^{[3
,4
]}

Liacini, Abdelhamid ^{[3
,4
]}

机构：

[1] Lahey Hosp & Med Ctr, Dept Pharm, Burlington, MA 01805 USA

[2] Temple Univ Hosp & Med Sch, Dept Pharm, Philadelphia, PA 19140 USA

[3] Temple Univ Hosp & Med Sch, Immunogenet Lab, Philadelphia, PA 19140 USA

[4] Lewis Katz Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19140 USA

[5] Lewis Katz Sch Med, Heart & Vasc Inst, Sect Cardiol, Philadelphia, PA 19140 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 04期

关键词：

orthotopic heart transplantation; autoantibodies; rejection; antibody-mediated rejection; AT(1)R; NON-HLA ANTIBODIES; TYPE-1 RECEPTOR ANTIBODIES; IMPACT;

D O I：

10.3390/ijms25042218

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.

引用

页数：7

共 22 条

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