Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients

被引：1

作者：

Hilma, Rizka Farah ^{[1
]}

Widaty, Sandra ^{[1
,3
]}

Marissa, Melani ^{[1
]}

Ilyas, Muhammad ^{[2
]}

机构：

[1] Univ Indonesia, Dr Cipto Mangunkusumo Natl Hosp, Fac Med, Dept Dermatol & Venereol, Jakarta, Indonesia

[2] Univ Indonesia, Fac Med, Dept Community Med Sci, Jakarta, Indonesia

[3] Univ Indonesia, Dr Cipto Mangunkusumo Natl Hosp, Fac Med, Dept Dermatol & Venereol, Cent Jakarta 10430, Dki Jakarta, Indonesia

来源：

DERMATOLOGY REPORTS | 2023年 / 15卷 / 04期

关键词：

vitamin D; vitamin D receptor; bacteriological index; leprosy; sun exposure; CALCIUM-ABSORPTION; SUN EXPOSURE; WOMEN;

D O I：

10.4081/dr.2023.9705

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Macrophages respond against Mycobacterium leprae infection through interacting with vitamin D and vitamin D receptor (VDR). There has been no study analyzing the association between vitamin D and VDR with bacteriological index (BI) in leprosy patients in Indonesia. To analyze the serum level of 25hydroxyvitamin D (25(OH)D) and plasma level of VDR as well as their association with BI in leprosy patients in Indonesia. This is a cross-sectional study. Serum level of 25(OH)D was assessed with in vitro chemiluminescent immunoassay. Plasma level of VDR was assessed with enzyme linked immunosorbent assay method. Median serum level of 25(OH)D was 12.68 ng/mL. There was no correlation between serum level of 25(OH)D and BI (r=0.033; p=0.869). Median plasma level of VDR was 1.36 ng/mL. There was no correlation between plasma level of VDR and BI (r=0.063; p=0.749) and no significant association between BI and serum level of 25(OH) and plasma level of VDR (R2=0.055). There was no association between serum level of 25(OH)D and plasma level of VDR with BI in leprosy patients.

引用

页数：6

共 30 条

[1]

Amirudin MD, 2003, Kusta, V2nd, P12

[2]

Cahyani AD, 2016, INT C HLTH WELL BEIN

[3]

Dewi IAK, 2016, Kadar 25-Hydroxyvitamin D Plasma Berkorelasi Negatif dengan Indeks Bakteri pada Penderita kusta

[4] EVIDENCE OF AN AGE-RELATED DECREASE IN INTESTINAL RESPONSIVENESS TO VITAMIN-D - RELATIONSHIP BETWEEN SERUM 1,25-DIHYDROXYVITAMIN-D(3) AND INTESTINAL VITAMIN-D RECEPTOR CONCENTRATIONS IN NORMAL WOMEN [J].