Phosphatidylserine transport in cell life and death

被引：25

作者：

Copic, Alenka ^{[1
]}

Dieudonne, Thibaud ^{[2
]}

Lenoir, Guillaume ^{[2
]}

机构：

[1] Univ Montpellier, Ctr Rech Biol Cellulaire Montpellier CRBM, CNRS, F-34293 Montpellier 05, France

[2] Univ Paris Saclay, Inst Integrat Biol Cell, CEA, CNRS, F-91198 Gif Sur Yvette, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2023年 / 83卷

关键词：

PLASMA-MEMBRANE; FLIPPASE; ATPASE; ER;

D O I：

10.1016/j.ceb.2023.102192

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphatidylserine (PS) is a negatively charged glycer-ophospholipid found mainly in the plasma membrane (PM) in the late secretory/endocytic compartments, where it regulates cellular activity and can mediate apoptosis. Export of PS from the endoplasmic reticulum, its site of synthesis, to other com-partments, and its transbilayer asymmetry must therefore precisely regulated. We review recent findings on nonvesicular transport of PS by lipid transfer proteins (LTPs) at membrane contact sites, on PS flip-flop between membrane leaflets by flippases and scramblases, and on PS nanoclustering at the PM. We also discuss emerging data on cooperation between scramblases and LTPs, how perturbation of PS distribution lead to disease, and the specific role of PS in viral infection.

引用

页数：8

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