Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis

被引：10

作者：

Xiao, Haoxiang ^{[1
]}

Xie, Yuqiao ^{[1
]}

Xi, Kaiwen ^{[1
]}

Xie, Jinyi ^{[1
]}

Liu, Mingyue ^{[2
]}

Zhang, Yangming ^{[1
]}

Cheng, Zishuo ^{[1
]}

Wang, Wenting ^{[1
]}

Guo, Baolin ^{[1
]}

Wu, Shengxi ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Basic Med, Dept Neurobiol, Xian 710032, Peoples R China

[2] Yanan Univ, Sch Med, Yanan, Peoples R China

来源：

AGING AND DISEASE | 2023年 / 14卷 / 05期

关键词：

aging; sirtuin; fibrosis; neurodegenerative diseases; excessive extracellular matrix; FATTY-ACID OXIDATION; AMYOTROPHIC-LATERAL-SCLEROSIS; INDUCED CARDIAC FIBROSIS; PYRUVATE-KINASE M2; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; GENE-EXPRESSION; CANCER-CELLS; SIRT3; AUTOPHAGY;

D O I：

10.14336/AD.2023.0203

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is a natural and complex biological process that is associated with widespread functional declines in numerous physiological processes, terminally affecting multiple organs and tissues. Fibrosis and neurodegenerative diseases (NDs) often occur with aging, imposing large burdens on public health worldwide, and there are currently no effective treatment strategies for these diseases. Mitochondrial sirtuins (SIRT3-5), which are members of the sirtuin family of NAD(+)-dependent deacylases and ADP-ribosyltransferases, are capable of regulating mitochondrial function by modifying mitochondrial proteins that participate in the regulation of cell survival under various physiological and pathological conditions. A growing body of evidence has revealed that SIRT3-5 exert protective effects against fibrosis in multiple organs and tissues, including the heart, liver, and kidney. SIRT3-5 are also involved in multiple age-related NDs, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Furthermore, SIRT3-5 have been noted as promising targets for antifibrotic therapies and the treatment of NDs. This review systematically highlights recent advances in knowledge regarding the role of SIRT3-5 in fibrosis and NDs and discusses SIRT3-5 as therapeutic targets for NDs and fibrosis.

引用

页码：1583 / 1605

页数：23

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