Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort

被引：1

作者：

Salmen, Anke ^{[1
,2
,3
]}

Hoepner, Robert ^{[2
,3
]}

Fleischer, Vinzenz ^{[4
]}

Heldt, Milena ^{[4
]}

Gisevius, Barbara ^{[1
]}

Motte, Jeremias ^{[1
]}

Ruprecht, Klemens ^{[5
,6
,7
,8
]}

Schneider, Ruth ^{[1
,9
]}

Fisse, Anna Lena ^{[1
]}

Grueter, Thomas ^{[1
]}

Lukas, Carsten ^{[1
,9
]}

Berthele, Achim ^{[10
]}

Giglhuber, Katrin ^{[10
]}

Flaskamp, Martina ^{[10
]}

Muehlau, Mark ^{[10
]}

Kirschke, Jan ^{[11
]}

Bittner, Stefan ^{[4
]}

Groppa, Sergiu ^{[4
]}

Luessi, Felix ^{[4
]}

Bayas, Antonios ^{[12
]}

Meuth, Sven ^{[13
]}

Heesen, Cristoph ^{[14
]}

Trebst, Corinna ^{[15
]}

Wildemann, Brigitte ^{[16
]}

Then Bergh, Florian ^{[17
]}

Antony, Gisela ^{[18
]}

Kuempfel, Tania ^{[19
]}

Paul, Friedemann ^{[5
,6
,7
,8
]}

Nischwitz, Sandra ^{[20
]}

Tumani, Hayrettin ^{[21
]}

Zettl, Uwe ^{[22
]}

Hemmer, Bernhard ^{[10
,23
]}

Wiendl, Heinz ^{[24
]}

Zipp, Frauke ^{[4
]}

Gold, Ralf ^{[1
]}

机构：

[1] Ruhr Univ Bochum, St Josef Hosp Bochum, Dept Neurol, Gudrunstr 56, D-44791 Bochum, Germany

[2] Univ Hosp Bern, Dept Neurol, Inselspital, Bern, Switzerland

[3] Univ Bern, Bern, Switzerland

[4] Univ Med Ctr Johannes Gutenberg Univ Mainz, Dept Neurol, Focus Program Translat Neurosci FTN & Immunotherap, Rhine Main Neurosci Network Rmn, Mainz, Germany

[5] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany

[6] Max Delbrueck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany

[7] Max Delbrueck Ctr Mol Med, NeuroCure Clin Res Ctr, Berlin, Germany

[8] Charite Univ Med Berlin, Berlin, Germany

[9] Ruhr Univ Bochum, St Josef Hosp Bochum, Inst Neuroradiol, Bochum, Germany

[10] Tech Univ Munich, Dept Neurol, Klinikum Rechts Isar, Munich, Germany

[11] Tech Univ Munich, Dept Neuroradiol, Klinikum Rechts Isar, Munich, Germany

[12] Univ Augsburg, Fac Med, Dept Neurol, Augsburg, Germany

[13] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Neurol, Dusseldorf, Germany

[14] Univ Hosp Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[15] Hannover Med Sch, Dept Neurol, Hannover, Germany

[16] Univ Hosp Heidelberg, Dept Neurol, Mol Neuroimmunol Grp, Heidelberg, Germany

[17] Univ Leipzig, Dept Neurol, Leipzig, Germany

[18] Philipps Univ Marburg, Cent Informat Off, German Competence Network Multiple Sclerosis, Marburg, Germany

[19] Ludwig Maximilian Univ Munich, Univ Hosp, Inst Clin Neuroimmunol, Munich, Germany

[20] Max Planck Inst Psychiat, Munich, Germany

[21] Univ Ulm, Dept Neurol, Ulm, Germany

[22] Univ Rostock, Dept Neurol, Neuroimmunol Sect, Rostock, Germany

[23] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[24] Univ Hosp, Inst Translat Neurol, Med Fac, Dept Neurol, Munster, Germany

来源：

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS | 2023年 / 16卷

关键词：

CIS; clinically isolated syndrome; cohort study; depression; MRI; MS; neuropsychological symptoms; relapse; sex; smoking; vitamin D; VITAMIN-D; RISK-FACTOR; FATIGUE; ANXIETY; IMPAIRMENT; DISABILITY; CRITERIA; SMOKING;

D O I：

10.1177/17562864231197309

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Depression has a major impact on the disease burden of multiple sclerosis (MS). Analyses of overlapping MS and depression risk factors [smoking, vitamin D (25-OH-VD) and Epstein-Barr virus (EBV) infection] and sex, age, disease characteristics and neuroimaging features associated with depressive symptoms in early MS are scarce.Objectives: To assess an association of MS risk factors with depressive symptoms within the German NationMS cohort.Design: Cross-sectional analysis within a multicenter observational study.Methods: Baseline data of n = 781 adults with newly diagnosed clinically isolated syndrome or relapsing-remitting MS qualified for analysis. Global and region-specific magnetic resonance imaging (MRI)-volumetry parameters were available for n = 327 patients. Association of demographic factors, MS characteristics and risk factors [sex, age, smoking, disease course, presence of current relapse, expanded disability status scale (EDSS) score, fatigue (fatigue scale motor cognition), 25-OH-VD serum concentration, EBV nuclear antigen-1 IgG (EBNA1-IgG) serum levels] and depressive symptoms (Beck Depression Inventory-II, BDI-II) was tested as a primary outcome by multivariable linear regression. Non-parametric correlation and group comparison were performed for associations of MRI parameters and depressive symptoms.Results: Mean age was 34.3 years (95% confidence interval: 33.6-35.0). The female-to-male ratio was 2.3:1. At least minimal depressive symptoms (BDI-II > 8) were present in n = 256 (32.8%), 25-OH-VD deficiency (<20 ng/ml) in n = 398 (51.0%), n = 246 (31.5%) participants were smokers. Presence of current relapse [coefficient (c) = 1.48, p = 0.016], more severe fatigue (c = 0.26, p < 0.0001), lower 25-OH-VD (c = -0.03, p = 0.034) and smoking (c = 0.35, p = 0.008) were associated with higher BDI-II scores. Sex, age, disease course, EDSS, month of visit, EBNA1-IgG levels and brain volumes at baseline were not.Conclusion: Depressive symptoms need to be assessed in early MS. Patients during relapse seem especially vulnerable to depressive symptoms. Contributing factors such as fatigue, vitamin D deficiency and smoking, could specifically be targeted in future interventions and should be investigated in prospective studies.

引用

页数：12

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