C-N Axially Chiral Heterobiaryl Isoquinolinone Skeletons Construction via Cobalt-Catalyzed Atroposelective C-H Activation/Annulation

Herein, the atroposelective construction of isoquinolinonesbearinga C-N chiral axis has been successfully developed via a Co-catalyzedC-H bond activation and annulation process. This conversioncan be effectively carried out in an environmentally friendly oxygenatmosphere to generate the target C-N axially chiral frameworkswith excellent reactivities and enantioselectivities (up to >99%ee)in the absence of any additives. Additionally, the current protocolhas proved to be an alternative approach for the C-N axialarchitectures fabrication under electrochemical conditions for cobalt/Saloxcatalysis, and this strategy allowed the efficient and atom-economicalsynthesis of various axially chiral isoquinolinones under mild reactionconditions.