Epigenetic Alterations from Barrett's Esophagus to Esophageal Adenocarcinoma

被引：7

作者：

Ergun, Pelin ^{[1
,2
]}

Kipcak, Sezgi ^{[1
,3
]}

Bor, Serhat ^{[1
]}

机构：

[1] Ege Univ, Fac Med, Div Gastroenterol, Ege Reflux Study Grp, TR-35040 Izmir, Turkiye

[2] Ege Univ, Fac Med, Dept Med Biochem, TR-35040 Izmir, Turkiye

[3] Ege Univ, Fac Med, Dept Med Biol, TR-35040 Izmir, Turkiye

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 09期

关键词：

Barrett's esophagus; adenocarcinoma; epigenetics; methylations; miRNA; PROMOTER HYPERMETHYLATION; E-CADHERIN; NEOPLASTIC PROGRESSION; MICRORNA EXPRESSION; TUMOR-SUPPRESSOR; MALIGNANT PROGRESSION; MOLECULAR ALTERATIONS; HISTONE DEACETYLASES; GASTRIC-CANCER; EARLY EVENT;

D O I：

10.3390/ijms24097817

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Barrett's esophagus (BE) is a disease entity that is a sequela of chronic gastroesophageal reflux disease that may result in esophageal adenocarcinoma (EAC) due to columnar epithelial dysplasia. The histological degree of dysplasia is the sole biomarker frequently utilized by clinicians. However, the cost of endoscopy and the fact that the degree of dysplasia does not progress in many patients with BE diminish the effectiveness of histological grading as a perfect biomarker. Multiple or more quantitative biomarkers are required by clinicians since early diagnosis is crucial in esophageal adenocancers, which have a high mortality rate. The presence of epigenetic factors in the early stages of this neoplastic transformation holds promise as a predictive biomarker. In this review, current studies on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) that have been discovered during the progression from BE dysplasia to EAC were collated.

引用

页数：18

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