Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects

被引：8
作者：
Chen, Yusha [1 ]
Liu, Xuefeng [2 ,3 ]
Tong, Zhaohui [1 ]
机构：
[1] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China
[2] Ohio State Univ, Coll Med, OSU Comprehens Canc Ctr, Dept Pathol, Columbus, OH 43210 USA
[3] Ohio State Univ, OSU Comprehens Canc Ctr, Dept Urol & Radiat Oncol, Coll Med, Columbus, OH 43210 USA
来源：
CELLS | 2023年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
mesenchymal stem cells; radiation-induced pulmonary fibrosis; exosomes; therapy; INDUCED LUNG INJURY; STROMAL CELLS; MECHANISMS; MIGRATION; THERAPY; ROLES; TRANSITION; SECRETION; ADHESION;
D O I：
10.3390/cells12010006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Radiation-induced pulmonary fibrosis (RIPF) is a general and fatal side effect of radiotherapy, while the pathogenesis has not been entirely understood yet. By now, there is still no effective clinical intervention available for treatment of RIPF. Recent studies revealed mesenchymal stromal cells (MSCs) as a promising therapy treatment due to their homing and differentiation ability, paracrine effects, immunomodulatory effects, and MSCs-derived exosomes. Nevertheless, problems and challenges in applying MSCs still need to be taken seriously. Herein, we reviewed the mechanisms and challenges in the applications of MSCs in treating RIPF.
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页数：10
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