Fabrication strategies for metal-organic framework electrochemical biosensors and their applications

Metal-organic frameworks (MOFs) are a class of functional porous three-dimensional framework mate-rials exhibiting unique chemical properties. Owing to the multifunctional nature of MOFs including their electroactive functionality and structural porosity, significant progress has been achieved in the advance-ment of MOF-based electrochemical sensors. This review focuses on innovations over the past decade in electrochemical sensor systems based on MOFs and their composites. The relationships between the elec-trode construction strategies and sensing performance are discussed, in addition to shortcomings and limitations in the applications of these sensors. On this basis, we discuss the future scope and propose further directions for MOF-based electrochemical sensors.(c) 2022 Published by Elsevier B.V.