Systemic and ocular associations in pediatric patients undergoing cataract surgery

被引:3
作者
Nihalani, Bharti R. [1 ]
VanderVeen, Deborah K. [1 ]
机构
[1] Harvard Med Sch, Boston Childrens Hosp, 300 Longwood Ave, Boston, MA 02115 USA
关键词
Pediatric cataract; Systemic associations with pediatric cataract; Ocular associations with pediatric cataract; Systemic associations; Pediatric cataract surgery; CHILDHOOD CATARACT; SURGICAL-TREATMENT; EPIDEMIOLOGY; DISORDERS; BLINDNESS; CHILDREN; PERIOD;
D O I
10.1007/s00417-022-05802-7
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose Evaluation for systemic diagnosis is an important part of pediatric cataract management. While there are reports on associated systemic and ocular associations in children with infantile cataracts, reports specifying associations in large cohorts of children undergoing cataract surgery are lacking. Methods Retrospective chart review of consecutive patients undergoing cataract surgery at a pediatric tertiary referral center during 30-year period was performed. Associated systemic and ocular associations were recorded. The etiologies were analyzed depending on laterality, age, and gender. Results Seven-hundred twenty-seven patients (1135 eyes) were included for analysis: 408 (56%) with bilateral and 319 (44%) with unilateral cataract. An identifiable cause for cataract was identified in 66% (270/408) bilateral and 55% (176/319) unilateral cataract patients. Hereditary cataract accounted for 22% of bilateral cataracts. An underlying syndrome or genetic diagnosis was found in 24% bilateral (97/408, 86 genetic/syndromic, 11 metabolic) but only in 2% of unilateral cases (5/319). Cataracts were the result of treatment for cancer, or other systemic conditions requiring steroids, in 60/408 bilateral (15%) and 15/319 (5%) unilateral cataract patients. In contrast, unilateral cataracts had higher ocular associations (49%, 156/319) than bilateral cataracts (6%, 23/408) primarily ocular trauma (20%, 64/319) and persistent fetal vasculature (20%, 62/319). Conclusion Clinicians should be aware of potential systemic and ocular associations among children with visually significant cataracts. Those with no family history of juvenile cataract should be evaluated for systemic associations, and referral to genetics may be warranted in select cases.
引用
收藏
页码:241 / 246
页数:6
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