Immunoliposomes as an emerging nanocarrier for breast cancer therapy

被引:31
作者
Parveen, Neha [1 ]
Abourehab, Mohammed A. S. [2 ]
Shukla, Rahul [3 ]
Thanikachalam, Punniyakoti Veeraveedu [4 ]
Jain, Gaurav Kumar [5 ]
Kesharwani, Prashant [1 ,6 ,7 ]
机构
[1] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India
[2] Umm Al Qura Univ, Coll Pharm, Dept Pharmaceut, Mecca 21955, Saudi Arabia
[3] Natl Inst Pharmaceut Educ & Res Raebareli, Dept Pharmaceut, Lucknow, UP, India
[4] Saveetha Inst Med & Tech Sci SIMATS, Saveetha Coll Pharm, Dept Pharmaceut Chem, Kanchipuram Chennai Rd, Chennai 602105, Tamil Nadu, India
[5] Delhi Pharmaceut Sci & Res Univ, Ctr Adv Formulat & Technol CAFT, Pushp Vihar,Govt NCT Delhi, New Delhi 110017, India
[6] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Ctr Transdisciplinary Res, Dept Pharmacol, Chennai, India
[7] Chandigarh Univ, Univ Inst Pharm Sci, Mohali, Punjab, India
关键词
Breast cancer; Immunoliposome; Liposome; Antibody; Nanocarriers; Chemotherapy; HER2; EGFR; HB-EGF; GROWTH-FACTOR; ANTICANCER DRUG; MACROMOLECULAR THERAPEUTICS; ANTI-HER2; IMMUNOLIPOSOMES; SENSITIVE IMMUNOLIPOSOMES; LIPID NANOPARTICLES; DELIVERY; LIPOSOMES; CHEMOTHERAPY; TARGET;
D O I
10.1016/j.eurpolymj.2022.111781
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The most prevalent non-cutaneous carcinoma in women and the second most prevalent tumour-related condition is breast cancer. There are significant therapeutic choices for treating breast cancer, and all come with adverse reactions. Innovative nanotechnologies showed promise for treating or focusing on breast cancer. Novel nanocarriers for the transport of chemotherapeutics were introduced by developments in protein engineering which completely changed nanomedicine. Recent research has focused on developing components that concurrently include drugs and targeting the site of illness. This article complements existing reviews on liposomal drug delivery by emphasising immunoliposome tumour targeting and summarising numerous experiments of immunoliposome assessment in vivo and in vitro with regard to therapeutic potential, structural liposomal parameters, and the needs of the target sites. Immunoliposomes have been suggested as a promising therapeutic delivery device for the therapy of breast cancer. In this review, we highlight current developments of immunoliposome formulation that synergistically demonstrate distinct target-cell associations while combining or loading with a variety of cytotoxic drugs.
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页数:15
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