?9-Tetrahydrocannabinol stimulation of estrogen receptor-positive MCF-7 breast cancer cell migration: Interfering interaction with the estrogenic milieu

被引：2
作者：
Takeda, Shuso [1 ,3 ,5 ]
Hirao-Suzuki, Masayo [2 ]
Aramaki, Hironori [3 ]
Watanabe, Kazuhito [4 ,5 ]
机构：
[1] Fukuyama Univ, Fac Pharm & Pharmaceut Sci, Lab Mol Life Sci, Sanzou 1,Gakuen Cho, Fukuyama, Hiroshima 7290292, Japan
[2] Hiroshima Int Univ, Fac Pharmaceut Sci, Lab Xenobiot Metab & Environm Toxicol, 5-1-1 Hiro Koshingai, Kure, Hiroshima 7370112, Japan
[3] Daiichi Univ Pharm, Dept Mol Biol, 22-1 Tamagawa Cho,Minami Ku, Fukuoka 8158511, Japan
[4] Daiichi Univ Pharm, Ctr Supporting Pharmaceut Educ, 22-1 Tamagawa Cho,Minami Ku, Fukuoka 8158511, Japan
[5] Hokuriku Univ, Org Frontier Res Prevent Pharmaceut Sci, Ho 3 Kanagawa Machi, Kanazawa 9201181, Japan
来源：
FORENSIC TOXICOLOGY | 2023年 / 41卷 / 02期
关键词：
delta(9)-Tetrahydrocannabinol; Migration; MCF-7; cells; Estrogen receptor; ENDOCRINE-DISRUPTING CHEMICALS; ACID 2-HYDROXYLASE FA2H; CANNABIDIOLIC ACID; DELTA(9)-TETRAHYDROCANNABINOL; MARIJUANA; DELTA-9-TETRAHYDROCANNABINOL; GROWTH; PROLIFERATION; INHIBITOR; GENE;
D O I：
10.1007/s11419-022-00655-5
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Purpose The effects of extended delta(9)-tetrahydrocannabinol (delta(9)-THC) exposure on estrogen receptor-positive human breast cancer MCF-7 cells have been investigated; however, the effects of delta(9)-THC exposure for a shorter duration remain unclear. In this study, we sought to study whether delta(9)-THC stimulates the migration of MCF-7 cells under both estrogenic and estrogen-deprived conditions over a short period (approximately 6 h). Methods MCF-7 cells were treated with delta(9)-THC under estrogenic or estrogen-deprived conditions, and cell migration was subsequently analyzed. Results delta(9)-THC-stimulated migration of MCF-7 cells 6 h after exposure was only observed in the estrogen-deprived condition. However, delta(9)-THC-mediated migration was counteracted under estrogenic conditions without affecting cell proliferation and estrogen receptor expression during this period. Conclusions delta(9)-THC can stimulate MCF-7 cell migration under estrogen-deprived conditions; however, there is an interfering interaction between delta(9)-THC and the estrogenic milieu that influences the migration of MCF-7 cells.
引用
收藏
页码：287 / 293
页数：7
相关论文
共 41 条
  • [11] Phytocannabinoids beyond the Cannabis plant - do they exist?
    Gertsch, Juerg
    Pertwee, Roger G.
    Di Marzo, Vincenzo
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (03) : 523 - 529
  • [12] GILL EW, 1972, BIOCHEM PHARMACOL, V21, P2237, DOI 10.1016/0006-2952(72)90039-1
  • [13] Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics
    Heuberger, Jules A. A. C.
    Guan, Zheng
    Oyetayo, Olubukayo-Opeyemi
    Klumpers, Linda
    Morrison, Paul D.
    Beumer, Tim L.
    van Gerven, Joop M. A.
    Cohen, Adam F.
    Freijer, Jan
    [J]. CLINICAL PHARMACOKINETICS, 2015, 54 (02) : 209 - 219
  • [14] Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration
    Hirao-Suzuki, Masayo
    Koga, Takayuki
    Sakai, Genki
    Kobayashi, Takanobu
    Ishii, Yuji
    Miyazawa, Hiroshi
    Takiguchi, Masufumi
    Sugihara, Narumi
    Toda, Akihisa
    Ohara, Masahiro
    Takeda, Shuso
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 531 (02) : 215 - 222
  • [15] Metalloestrogenic effects of cadmium are absent in long-term estrogen-deprived MCF-7 cells: Evidence for the involvement of constitutively activated estrogen receptor a and very low expression of G protein-coupled estrogen receptor 1
    Hirao-Suzuki, Masayo
    Takeda, Shuso
    Kodama, Yasushi
    Takiguchi, Masufumi
    Toda, Akihisa
    Ohara, Masahiro
    [J]. TOXICOLOGY LETTERS, 2020, 319 : 22 - 30
  • [16] Repeated Exposure to 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor β (ERβ)-Dependent Manner
    Hirao-Suzuki, Masayo
    Takeda, Shuso
    Okuda, Katsuhiro
    Takiguchi, Masufumi
    Yoshihara, Shin'ichi
    [J]. MOLECULAR PHARMACOLOGY, 2019, 95 (03) : 260 - 268
  • [17] DETERMINATION OF DELTA-1-TETRAHYDROCANNABINOL IN HUMAN FAT BIOPSIES FROM MARIHUANA USERS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
    JOHANSSON, E
    NOREN, K
    SJOVALL, J
    HALLDIN, MM
    [J]. BIOMEDICAL CHROMATOGRAPHY, 1989, 3 (01) : 35 - 38
  • [18] Bisphenol A Induces Sox2 in ER+ Breast Cancer Stem-Like Cells
    Lillo, M. Angeles
    Nichols, Cydney
    Seagroves, Tiffany N.
    Miranda-Carboni, Gustavo A.
    Krum, Susan A.
    [J]. HORMONES & CANCER, 2017, 8 (02): : 90 - 99
  • [19] The 26S proteasome is required for estrogen receptor-α and coactivator turnover and for efficient estrogen receptor-α transactivation
    Lonard, DM
    Nawaz, Z
    Smith, CL
    O'Malley, BW
    [J]. MOLECULAR CELL, 2000, 5 (06) : 939 - 948
  • [20] TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion
    Lu, Hou-Gen
    Zhan, Wang
    Yan, Lin
    Qin, Rui-Ying
    Yan, Yi-Peng
    Yang, Zhen-Jiang
    Liu, Gui-Chao
    Li, Gui-Qin
    Wang, Hai-Feng
    Li, Xing-Liang
    Li, Zhi
    Gao, Lu
    Chen, Guo-Qing
    [J]. MOLECULAR MEDICINE REPORTS, 2014, 10 (05) : 2595 - 2600
12345