Roles of the CCR4-Not complex in translation and dynamics of co-translation events

被引：6
作者：
Collart, Martine A. [1 ]
Audebert, Lena [1 ]
Bushell, Martin [2 ,3 ]
机构：
[1] Univ Geneva, Inst Genet & Genom Geneva, Fac Med, Dept Microbiol & Mol Med, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland
[2] Canc Res UK Beatson Inst, Glasgow, Scotland
[3] Univ Glasgow, Sch Canc Sci, Glasgow, Scotland
来源：
WILEY INTERDISCIPLINARY REVIEWS-RNA | 2024年 / 15卷 / 01期
关键词：
Ccr4-Not; codon optimality; Not5 ribosome interaction; repression of translation initiation; translation elongation dynamics; MESSENGER-RNA DECAY; POLY(A) TAIL LENGTH; DIFFERENTIALLY AFFECTS; TRANSCRIPTION FACTOR; DEADENYLASE COMPLEX; STRUCTURAL BASIS; CAF1; PROTEINS; DEGRADATION; REVEALS; GENE;
D O I：
10.1002/wrna.1827
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Ccr4-Not complex is a global regulator of mRNA metabolism in eukaryotic cells that is most well-known to repress gene expression. Delivery of the complex to mRNAs through a multitude of distinct mechanisms accelerates their decay, yet Ccr4-Not also plays an important role in co-translational processes, such as co-translational association of proteins and delivery of translating mRNAs to organelles. The recent structure of Not5 interacting with the translated ribosome has brought to light that embedded information within the codon sequence can be monitored by recruitment of the Ccr4-Not complex to elongating ribosomes. Thereby, the Ccr4-Not complex is empowered with regulatory decisions determining the fate of proteins being synthesized and their encoding mRNAs. This review will focus on the roles of the complex in translation and dynamics of co-translation events.This article is categorized under:Translation > MechanismsTranslation > Regulation
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页数：22
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