Roles of the CCR4-Not complex in translation and dynamics of co-translation events

被引：6
作者：
Collart, Martine A. [1 ]
Audebert, Lena [1 ]
Bushell, Martin [2 ,3 ]
机构：
[1] Univ Geneva, Inst Genet & Genom Geneva, Fac Med, Dept Microbiol & Mol Med, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland
[2] Canc Res UK Beatson Inst, Glasgow, Scotland
[3] Univ Glasgow, Sch Canc Sci, Glasgow, Scotland
来源：
WILEY INTERDISCIPLINARY REVIEWS-RNA | 2024年 / 15卷 / 01期
关键词：
Ccr4-Not; codon optimality; Not5 ribosome interaction; repression of translation initiation; translation elongation dynamics; MESSENGER-RNA DECAY; POLY(A) TAIL LENGTH; DIFFERENTIALLY AFFECTS; TRANSCRIPTION FACTOR; DEADENYLASE COMPLEX; STRUCTURAL BASIS; CAF1; PROTEINS; DEGRADATION; REVEALS; GENE;
D O I：
10.1002/wrna.1827
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Ccr4-Not complex is a global regulator of mRNA metabolism in eukaryotic cells that is most well-known to repress gene expression. Delivery of the complex to mRNAs through a multitude of distinct mechanisms accelerates their decay, yet Ccr4-Not also plays an important role in co-translational processes, such as co-translational association of proteins and delivery of translating mRNAs to organelles. The recent structure of Not5 interacting with the translated ribosome has brought to light that embedded information within the codon sequence can be monitored by recruitment of the Ccr4-Not complex to elongating ribosomes. Thereby, the Ccr4-Not complex is empowered with regulatory decisions determining the fate of proteins being synthesized and their encoding mRNAs. This review will focus on the roles of the complex in translation and dynamics of co-translation events.This article is categorized under:Translation > MechanismsTranslation > Regulation
引用
收藏
页数：22
相关论文
共 50 条
  • [21] RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation
    Poetz, Fabian
    Corbo, Joshua
    Levdansky, Yevgen
    Spiegelhalter, Alexander
    Lindner, Doris
    Magg, Vera
    Lebedeva, Svetlana
    Schweiggert, Jorg
    Schott, Johanna
    Valkov, Eugene
    Stoecklin, Georg
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [22] Insights into the structure of the CCR4-NOT complex by electron microscopy
    Nasertorabi, Fariborz
    Batisse, Claire
    Diepholz, Meikel
    Suck, Dietrich
    Boettcher, Bettina
    FEBS LETTERS, 2011, 585 (14) : 2182 - 2186
  • [23] Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression
    Mathys, Hansruedi
    Basquin, Jerome
    Ozgur, Sevim
    Czarnocki-Cieciura, Mariusz
    Bonneau, Fabien
    Aartse, Aafke
    Dziembowski, Andrzej
    Nowotny, Marcin
    Conti, Elena
    Filipowicz, Witold
    MOLECULAR CELL, 2014, 54 (05) : 751 - 765
  • [24] The Ccr4-Not complex monitors the translating ribosome for codon optimality
    Buschauer, Robert
    Matsuo, Yoshitaka
    Sugiyama, Takato
    Chen, Ying-Hsin
    Alhusaini, Najwa
    Sweet, Thomas
    Ikeuchi, Ken
    Cheng, Jingdong
    Matsuki, Yasuko
    Nobuta, Risa
    Gilmozzi, Andrea
    Berninghausen, Otto
    Tesina, Petr
    Becker, Thomas
    Coller, Jeff
    Inada, Toshifumi
    Beckmann, Roland
    SCIENCE, 2020, 368 (6488) : 281 - +
  • [25] The architecture of the Schizosaccharomyces pombe CCR4-NOT complex
    Ukleja, Marta
    Cuellar, Jorge
    Siwaszek, Aleksandra
    Kasprzak, Joanna M.
    Czarnocki-Cieciura, Mariusz
    Bujnicki, Janusz M.
    Dziembowski, Andrzej
    Valpuesta, Jose M.
    NATURE COMMUNICATIONS, 2016, 7
  • [26] The control of elongation by the yeast Ccr4-Not complex
    Reese, Joseph C.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2013, 1829 (01): : 127 - 133
  • [27] Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex
    Akiyama, Taishin
    Yamamoto, Tadashi
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [28] Translational Capacity of a Cell Is Determined during Transcription Elongation via the Ccr4-Not Complex
    Gupta, Ishaan
    Villanyi, Zoltan
    Kassem, Sari
    Hughes, Christopher
    Panasenko, Olesya O.
    Steinmetz, Lars M.
    Collart, Martine A.
    CELL REPORTS, 2016, 15 (08): : 1782 - 1794
  • [29] Beyond the known functions of the CCR4-NOT complex in gene expression regulatory mechanisms New structural insights to unravel CCR4-NOT mRNA processing machinery
    Ukleja, Marta
    Maria Valpuesta, Jose
    Dziembowski, Andrzej
    Cuellar, Jorge
    BIOESSAYS, 2016, 38 (10) : 1048 - 1058
  • [30] Multi-Functional Regulation of 4E-BP Gene Expression by the Ccr4-Not Complex
    Okada, Hirokazu
    Schittenhelm, Ralf B.
    Straessle, Anna
    Hafen, Ernst
    PLOS ONE, 2015, 10 (03):
12345