Nickel-catalyzed cross-electrophile coupling of aryl thiols with aryl bromides via C-S bond activation

被引：34

作者：

Xu, Hao ^{[1
]}

He, Cai-Yu ^{[1
]}

Huo, Bo-Jie ^{[1
]}

Jing, Jia-Wen ^{[1
]}

Miao, Chengping ^{[2
]}

Rao, Weidong ^{[3
]}

Chu, Xue-Qiang ^{[1
]}

Zhou, Xiaocong ^{[1
,2
]}

Shen, Zhi-Liang ^{[1
]}

机构：

[1] Nanjing Tech Univ, Techn Inst Fluorochem TIF, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

[2] Jiaxing Univ, Coll Biol Chem Sci & Engn, 118 Jiahang Rd, Jiaxing 314001, Peoples R China

[3] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Prov Key Lab Chem & Utilizat Agro Forest, Nanjing 210037, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 20期

基金：

中国国家自然科学基金;

关键词：

CARBON-SULFUR; GRIGNARD-REAGENTS; DIRECT INSERTION; HALIDES; FUNCTIONALIZATION; COMPLEXES; ARYLATION; IODIDES; COBALT; CYCLIZATION;

D O I：

10.1039/d3qo01236k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of aryl thiols with aryl bromides usually provides thioethers as the major products, even in the presence of a transition metal catalyst and a zinc mediator. We report here a cross-electrophile coupling of aryl thiols with aryl bromides via C-S bond activation instead of S-H bond cleavage. The reaction proceeded effectively in the presence of a nickel catalyst, magnesium turnings, and lithium chloride in THF at room temperature to afford a variety of structurally diverse biaryls in moderate to good yields.

引用

页码：5171 / 5179

页数：9

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