Mechanochemical difluoromethylation of (thio)phenols and N-heterocycles

被引：2
作者：
Ford, Joseph [1 ]
Hopkin, Benjamin [1 ]
Sap, Jeroen B. I. [1 ]
Gouverneur, Veronique [1 ]
机构：
[1] Univ Oxford, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England
来源：
ISRAEL JOURNAL OF CHEMISTRY | 2023年 / 63卷 / 10-11期
基金：
英国工程与自然科学研究理事会;
关键词：
Carbenes; Difluoromethylation; Fluorine; Reactive intermediates; Solid-phase synthesis; REAGENT;
D O I：
10.1002/ijch.202300109
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report a minimalistic protocol for the solvent-free, mechanochemical difluoromethylation of (thio)phenols and N-heteroarenes using non-ozone depleting chlorodifluoromethyl phenyl sulfone as a difluorocarbene source. This mechanochemical difluoromethylation features a short reaction time, excellent functional group tolerance, and compatibility with complex biologically active scaffolds.
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页数：5
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