Targeting ferroptosis, a novel programmed cell death, for the potential of alcohol-related liver disease therapy

被引：12

作者：

Shi, Jing-Fen ^{[1
,2
,3
]}

Liu, Yu'e ^{[4
]}

Wang, Yan ^{[3
]}

Gao, Ru ^{[3
]}

Wang, Yi ^{[5
]}

Liu, Jun ^{[3
,6
]}

机构：

[1] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Inst Hlth Policy, Chengdu, Peoples R China

[2] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Hosp Management, Chengdu, Peoples R China

[3] Wenjiang Dist Peoples Hosp Chengdu, Chengdu, Peoples R China

[4] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Canc Ctr, Shanghai, Peoples R China

[5] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Crit Care Med, Chengdu, Peoples R China

[6] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Ultrasound Med, Chengdu, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

ferroptosis; ALD; ROS; GPx4; p53; ferroptosis inducers; ferroptosis inhibitors; HEPATIC IRON OVERLOAD; VITAMIN-E; UP-REGULATION; INHIBITION; EXPRESSION; MECHANISM; LIPROXSTATIN-1; FERROSTATIN-1; PEROXIDATION; PATHOGENESIS;

D O I：

10.3389/fphar.2023.1194343

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ferroptosis is a new iron-dependent cell death mode, which is different from the other types of programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is characterized by a process in which fatal lipids from lipid peroxidation accumulate in cells and eventually lead to cell death. Alcohol-related liver disease (ALD) is a type of liver injury caused by excessive alcohol intake. Alcohol-related liver disease is a broad-spectrum disease category, which includes fatty liver, steatohepatitis, hepatitis, cirrhosis, and hepatocellular tumors. Recent studies have found that ferroptosis is involved in the pathological development of non-viral liver diseases. Therefore, ferroptosis may be an ideal target for the treatment of non-viral liver diseases. In this review article, we will elaborate the molecular mechanism and regulatory mechanism of ferroptosis, explore the key role of ferroptosis in the Alcohol-related liver disease process, and summarize the existing targeted ferroptosis drugs and their feasibility for the treatment of Alcohol-related liver disease.

引用

页数：10