Nasal nitric oxide measurement in children for the diagnosis of primary ciliary dyskinesia: European Respiratory Society technical standard

被引：27

作者：

Beydon, Nicole ^{[1
,2
]}

Kouis, Panayiotis ^{[3
]}

Marthin, June K. ^{[4
]}

Latzin, Philipp ^{[5
]}

Colas, Murielle

Davis, Stephanie D. ^{[6
]}

Haarman, Eric ^{[7
]}

Harris, Amanda Lea ^{[8
,9
]}

Hogg, Claire ^{[10
,11
]}

Kilbride, Emma ^{[12
]}

Kuehni, Claudia E. ^{[5
,13
]}

Marangu, Diana ^{[14
]}

Nielsen, Kim G. ^{[4
,15
]}

Pendergrast, Catherine ^{[16
,17
]}

Robinson, Phil ^{[18
,19
,20
]}

Rumman, Nisreen ^{[21
,22
]}

Rutter, Matthew ^{[23
]}

Walker, Woolf T. ^{[8
,9
]}

Ferkol, Thomas ^{[6
]}

Lucas, Jane S. ^{[8
,9
]}

机构：

[1] Sorbonne Univ, Hop Armand Trousseau, AP HP, Unite Fonct Physiol Explorat Fonct Resp & Sommeil, Paris, France

[2] Sorbonne Univ, Hop St Antoine, Ctr Rech St Antoine, INSERM U938, Paris, France

[3] Univ Cyprus, Med Sch, Resp Physiol Lab, Nicosia, Cyprus

[4] Copenhagen Univ Hosp, Paediat Pulm Serv, Danish PCD Ctr Copenhagen, Rigshosp, Copenhagen, Denmark

[5] Univ Bern, Bern Univ Hosp, Dept Pediat, Div Pediat Resp Med & Allergol,Inselspital, Bern, Switzerland

[6] Univ North Carolina Chapel Hill, Dept Pediat, UNC Childrens, Sch Med, Chapel Hill, NC USA

[7] Vrije Univ Amsterdam, Emma Childrens Hosp, Dept Pediat Pulmonol, Amsterdam UMC, Amsterdam, Netherlands

[8] Univ Hosp Southampton NHS Fdn Trust, Primary Ciliary Dyskinesia Ctr, Southampton, England

[9] Univ Southampton, Primary Ciliary Dyskinesia Ctr, NIHR Southampton Resp Biomed Res Unit, Southampton, England

[10] Imperial Coll London, Royal Brompton Hosp, Dept Paediat Resp Med, London, England

[11] Imperial Coll London, Royal Brompton Hosp, Primary Ciliary Dyskinesia Ctr, London, England

[12] Childrens Hlth Ireland, Paediat Resp Lab, Dublin, Ireland

[13] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

[14] Univ Nairobi, Dept Paediat & Child Hlth, Nairobi, Kenya

[15] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[16] Womens & Childrens Hosp, Dept Resp & Sleep Med, Lung Funct Lab, Adelaide, Australia

[17] Univ South Australia, Innovat Implementat & Clin Translat Hlth IIMPACT R, Adelaide, Australia

[18] Royal Childrens Hosp, Dept Resp & Sleep Med, Parkville, Australia

[19] Univ Melbourne, Dept Paediat, Parkville, Australia

[20] Murdoch Childrens Res Inst, Parkville, Australia

[21] Al Quds Univ, Makassed Hosp, Dept Pediat, East Jerusalem, Palestine

[22] Caritas Baby Hosp, Bethlehem, Palestine

[23] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Lung Funct Dept, Cambridge, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2023年 / 61卷 / 04期

关键词：

ASPIRATION; VALUES; NO;

D O I：

10.1183/13993003.02031-2022

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Nasal nitric oxide (nNO) is extremely low in most people with primary ciliary dyskinesia (PCD) and its measurement is an important contributor to making the diagnosis. Existing guidelines and technical standards focus on nNO measurements in older, cooperative children using chemiluminescence analysers. However, measurements of nNO in pre-school-age children (age 2-5 years) may facilitate early diagnosis and electrochemical rather than chemiluminescence analysers are widely used. Pre-schoolers often need different methods to be employed when measuring nNO. Hence, a European Respiratory Society Task Force has developed this technical standard as the first step towards standardising sampling, analysis and reporting of nNO measured as part of the diagnostic testing for PCD in all age groups, including pre -school-age children. Furthermore, we considered both chemiluminescence and electrochemical analysers that are in use worldwide. There was a paucity of quality evidence for electrochemical analysers and sampling methods used in young children, and the Task Force proposes future research priorities to allow updates of this technical standard.

引用

页数：18

共 60 条

[1] Establishing normative nasal nitric oxide values in infants [J].