Updating the Adherence-Response for Oral Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Preexposure Prophylaxis Among Cisgender Women

被引：18

作者：

Anderson, Peter L. ^{[1
,5
]}

Marzinke, Mark A. ^{[2
,3
]}

Glidden, David, V ^{[4
]}

机构：

[1] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO USA

[2] Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD USA

[3] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[5] Univ Colorado, Dept Pharmaceut Sci, Anschutz Med Campus,V20-C238,12850 E Montview Blvd, Aurora, CO 80045 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 10期

基金：

美国国家卫生研究院;

关键词：

PrEP; sex differences; adherence; tenofovir; pharmacology; TRANSGENDER WOMEN; MEN; PREVENTION; CABOTEGRAVIR; TENOFOVIR; PHASE-3; RISK; SEX;

D O I：

10.1093/cid/ciad021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using intraerythrocytic tenofovir-diphosphate data from the emtricitabine/tenofovir disoproxil fumarate arms of HIV Prevention Trials Network (HPTN) 083 (men) and HPTN 084 (women), approximately 99% efficacy was achieved at a lower adherence threshold in HPTN 083 (>= 2 doses/week) compared with HPTN 084 (daily), suggesting higher adherence is necessary for women vs men.

引用

页码：1850 / 1853

页数：4

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