Updating the Adherence-Response for Oral Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Preexposure Prophylaxis Among Cisgender Women

被引：24

作者：

Anderson, Peter L. ^{[1
,5
]}

Marzinke, Mark A. ^{[2
,3
]}

Glidden, David, V ^{[4
]}

机构：

[1] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO USA

[2] Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD USA

[3] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[5] Univ Colorado, Dept Pharmaceut Sci, Anschutz Med Campus,V20-C238,12850 E Montview Blvd, Aurora, CO 80045 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 10期

基金：

美国国家卫生研究院;

关键词：

PrEP; sex differences; adherence; tenofovir; pharmacology; TRANSGENDER WOMEN; MEN; PREVENTION; CABOTEGRAVIR; TENOFOVIR; PHASE-3; RISK; SEX;

D O I：

10.1093/cid/ciad021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using intraerythrocytic tenofovir-diphosphate data from the emtricitabine/tenofovir disoproxil fumarate arms of HIV Prevention Trials Network (HPTN) 083 (men) and HPTN 084 (women), approximately 99% efficacy was achieved at a lower adherence threshold in HPTN 083 (>= 2 doses/week) compared with HPTN 084 (daily), suggesting higher adherence is necessary for women vs men.

引用

页码：1850 / 1853

页数：4

共 15 条

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Andrews, Chasity D. ;

Yueh, Yun Lan ;

Spreen, William R. ;

St Bernard, Leslie ;

Boente-Carrera, Mar ;

Rodriguez, Kristina ;

Gettie, Agegnehu ;

Russell-Lodrigue, Kasi ;

Blanchard, James ;

Ford, Susan ;

Mohri, Hiroshi ;

Cheng-Mayer, Cecilia ;

Hong, Zhi ;

Ho, David D. ;

Markowitz, Martin .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (270)

[2] Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus [J].

Andrews, Chasity D. ;

Spreen, William R. ;

Mohri, Hiroshi ;

Moss, Lee ;

Ford, Susan ;

Gettie, Agegnehu ;

Russell-Lodrigue, Kasi ;

Bohm, Rudolf P. ;

Cheng-Mayer, Cecilia ;

Hong, Zhi ;

Markowitz, Martin ;

Ho, David D. .

SCIENCE, 2014, 343 (6175) :1151-1154

[3] Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women [J].

Baeten, J. M. ;

Donnell, D. ;

Ndase, P. ;

Mugo, N. R. ;

Campbell, J. D. ;

Wangisi, J. ;

Tappero, J. W. ;

Bukusi, E. A. ;

Cohen, C. R. ;

Katabira, E. ;

Ronald, A. ;

Tumwesigye, E. ;

Were, E. ;

Fife, K. H. ;

Kiarie, J. ;

Farquhar, C. ;

John-Stewart, G. ;

Kakia, A. ;

Odoyo, J. ;

Mucunguzi, A. ;

Nakku-Joloba, E. ;

Twesigye, R. ;

Ngure, K. ;

Apaka, C. ;

Tamooh, H. ;

Gabona, F. ;

Mujugira, A. ;

Panteleeff, D. ;

Thomas, K. K. ;

Kidoguchi, L. ;

Krows, M. ;

Revall, J. ;

Morrison, S. ;

Haugen, H. ;

Emmanuel-Ogier, M. ;

Ondrejcek, L. ;

Coombs, R. W. ;

Frenkel, L. ;

Hendrix, C. ;

Bumpus, N. N. ;

Bangsberg, D. ;

Haberer, J. E. ;

Stevens, W. S. ;

Lingappa, J. R. ;

Celum, C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (05) :399-410

[4] Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial [J].

Baeten, Jared M. ;

Donnell, Deborah ;

Mugo, Nelly R. ;

Ndase, Patrick ;

Thomas, Katherine K. ;

Campbell, James D. ;

Wangisi, Jonathan ;

Tappero, Jordan W. ;

Bukusi, Elizabeth A. ;

Cohen, Craig R. ;

Katabira, Elly ;

Ronald, Allan ;

Tumwesigye, Elioda ;

Were, Edwin ;

Fife, Kenneth H. ;

Kiarie, James ;

Farquhar, Carey ;

John-Stewart, Grace ;

Kidoguchi, Lara ;

Coombs, Robert W. ;

Hendrix, Craig ;

Marzinke, Mark A. ;

Frenkel, Lisa ;

Haberer, Jessica E. ;

Bangsberg, David ;

Celum, Connie .

LANCET INFECTIOUS DISEASES, 2014, 14 (11) :1055-1064

[5] A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine [J].

Cottrell, Mackenzie L. ;

Yang, Kuo H. ;

Prince, Heather M. A. ;

Sykes, Craig ;

White, Nicole ;

Malone, Stephanie ;

Dellon, Evan S. ;

Madanick, Ryan D. ;

Shaheen, Nicholas J. ;

Hudgens, Michael G. ;

Wulff, Jacob ;

Patterson, Kristine B. ;

Nelson, Julie A. E. ;

Kashuba, Angela D. M. .

JOURNAL OF INFECTIOUS DISEASES, 2016, 214 (01) :55-64

[6] Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial [J].

Delany-Moretlwe, Sinead ;

Hughes, James P. ;

Bock, Peter ;

Ouma, Samuel Gurrion ;

Hunidzarira, Portia ;

Kalonji, Dishiki ;

Kayange, Noel ;

Makhema, Joseph ;

Mandima, Patricia ;

Mathew, Carrie ;

Spooner, Elizabeth ;

Mpendo, Juliet ;

Mukwekwerere, Pamela ;

Mgodi, Nyaradzo ;

Ntege, Patricia Nahirya ;

Nair, Gonasagrie ;

Nakabiito, Clemensia ;

Nuwagaba-Biribonwoha, Harriet ;

Panchia, Ravindre ;

Singh, Nishanta ;

Siziba, Bekezela ;

Farrior, Jennifer ;

Rose, Scott ;

Anderson, Peter L. ;

Eshleman, Susan H. ;

Marzinke, Mark A. ;

Hendrix, Craig W. ;

Beigel-Orme, Stephanie ;

Hosek, Sybil ;

Tolley, Elizabeth ;

Sista, Nirupama ;

Adeyeye, Adeola ;

Rooney, James F. ;

Rinehart, Alex ;

Spreen, William R. ;

Smith, Kimberly ;

Hanscom, Brett ;

Cohen, Myron S. ;

Hosseinipour, Mina C. .

LANCET, 2022, 399 (10337) :1779-1789

[7] Characterization of Human Immunodeficiency Virus (HIV) Infections in Women Who Received Injectable Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention: HPTN 084 [J].

Eshleman, Susan H. ;

Fogel, Jessica M. ;

Piwowar-Manning, Estelle ;

Chau, Gordon ;

Cummings, Vanessa ;

Agyei, Yaw ;

Richardson, Paul ;

Sullivan, Philip ;

Haines, Casey D. ;

Bushman, Lane R. ;

Petropoulos, Christos ;

Persaud, Deborah ;

Kofron, Ryan ;

Hendrix, Craig W. ;

Anderson, Peter L. ;

Farrior, Jennifer ;

Mellors, John ;

Adeyeye, Adeola ;

Rinehart, Alex ;

St Clair, Marty ;

Ford, Susan ;

Rooney, James F. ;

Mathew, Carrie-Anne ;

Hunidzarira, Portia ;

Spooner, Elizabeth ;

Mpendo, Juliet ;

Nair, Gonasagrie ;

Cohen, Myron S. ;

Hughes, James P. ;

Hosseinipour, Mina ;

Hanscom, Brett ;

Delany-Moretlwe, Sinead ;

Marzinke, Mark A. .

JOURNAL OF INFECTIOUS DISEASES, 2022, 225 (10) :1741-1749

[8] Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study [J].

Grant, Robert M. ;

Anderson, Peter L. ;

McMahan, Vanessa ;

Liu, Albert ;

Amico, K. Rivet ;

Mehrotra, Megha ;

Hosek, Sybil ;

Mosquera, Carlos ;

Casapia, Martin ;

Montoya, Orlando ;

Buchbinder, Susan ;

Veloso, Valdilea G. ;

Mayer, Kenneth ;

Chariyalertsak, Suwat ;

Bekker, Linda-Gail ;

Kallas, Esper G. ;

Schechter, Mauro ;

Guanira, Juan ;

Bushman, Lane ;

Burns, David N. ;

Rooney, James F. ;

Glidden, David V. .

LANCET INFECTIOUS DISEASES, 2014, 14 (09) :820-829

[9] Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women [J].

Landovitz, Raphael J. ;

Donnell, Deborah ;

Clement, Meredith E. ;

Hanscom, Brett ;

Cottle, Leslie ;

Coelho, Lara ;

Cabello, Robinson ;

Chariyalertsak, Suwat ;

Dunne, Eileen F. ;

Frank, Ian ;

Gallardo-Cartagena, Jorge A. ;

Gaur, Aditya H. ;

Gonzales, Pedro ;

Tran, Ha V. ;

Hinojosa, Juan C. ;

Kallas, Esper G. ;

Kelley, Colleen F. ;

Losso, Marcelo H. ;

Madruga, J. Valdez ;

Middelkoop, Keren ;

Phanuphak, Nittaya ;

Santos, Breno ;

Sued, Omar ;

Valencia Huamani, Javier ;

Overton, Edgar T. ;

Swaminathan, Shobha ;

del Rio, Carlos ;

Gulick, Roy M. ;

Richardson, Paul ;

Sullivan, Philip ;

Piwowar-Manning, Estelle ;

Marzinke, Mark ;

Hendrix, Craig ;

Li, Maoji ;

Wang, Zhe ;

Marrazzo, Jeanne ;

Daar, Eric ;

Asmelash, Aida ;

Brown, Todd T. ;

Anderson, Peter ;

Eshleman, Susan H. ;

Bryan, Marcus ;

Blanchette, Cheryl ;

Lucas, Jonathan ;

Psaros, Christina ;

Safren, Steven ;

Sugarman, Jeremy ;

Scott, Hyman ;

Eron, Joseph J. ;

Fields, Sheldon D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) :595-608

[10] Characterization of Human Immunodeficiency Virus (HIV) Infection in Cisgender Men and Transgender Women Who Have Sex With Men Receiving Injectable Cabotegravir for HIV Prevention: HPTN 083 [J].

Marzinke, Mark A. ;

Grinsztejn, Beatriz ;

Fogel, Jessica M. ;

Piwowar-Manning, Estelle ;

Li, Maoji ;

Weng, Lei ;

McCauley, Marybeth ;

Cummings, Vanessa ;

Ahmed, Shahnaz ;

Haines, Casey D. ;

Bushman, Lane R. ;

Petropoulos, Christos ;

Persaud, Deborah ;

Adeyeye, Adeola ;

Kofron, Ryan ;

Rinehart, Alex ;

St Clair, Marty ;

Rooney, James F. ;

Pryluka, Daniel ;

Coelho, Lara ;

Gaur, Aditya ;

Middelkoop, Keren ;

Phanuphak, Nittaya ;

Cohen, Myron S. ;

Hendrix, Craig W. ;

Anderson, Peter ;

Hanscom, Brett ;

Donnell, Deborah ;

Landovitz, Raphael J. ;

Eshleman, Susan H. .

JOURNAL OF INFECTIOUS DISEASES, 2021, 224 (09) :1581-1592

← 1 2 →

共 15 条

[1] A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge [J].

Andrews, Chasity D. ;

Yueh, Yun Lan ;

Spreen, William R. ;

St Bernard, Leslie ;

Boente-Carrera, Mar ;

Rodriguez, Kristina ;

Gettie, Agegnehu ;

Russell-Lodrigue, Kasi ;

Blanchard, James ;

Ford, Susan ;

Mohri, Hiroshi ;

Cheng-Mayer, Cecilia ;

Hong, Zhi ;

Ho, David D. ;

Markowitz, Martin .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (270)

[2] Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus [J].

Andrews, Chasity D. ;

Spreen, William R. ;

Mohri, Hiroshi ;

Moss, Lee ;

Ford, Susan ;

Gettie, Agegnehu ;

Russell-Lodrigue, Kasi ;

Bohm, Rudolf P. ;

Cheng-Mayer, Cecilia ;

Hong, Zhi ;

Markowitz, Martin ;

Ho, David D. .

SCIENCE, 2014, 343 (6175) :1151-1154

[3] Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women [J].

Baeten, J. M. ;

Donnell, D. ;

Ndase, P. ;

Mugo, N. R. ;

Campbell, J. D. ;

Wangisi, J. ;

Tappero, J. W. ;

Bukusi, E. A. ;

Cohen, C. R. ;

Katabira, E. ;

Ronald, A. ;

Tumwesigye, E. ;

Were, E. ;

Fife, K. H. ;

Kiarie, J. ;

Farquhar, C. ;

John-Stewart, G. ;

Kakia, A. ;

Odoyo, J. ;

Mucunguzi, A. ;

Nakku-Joloba, E. ;

Twesigye, R. ;

Ngure, K. ;

Apaka, C. ;

Tamooh, H. ;

Gabona, F. ;

Mujugira, A. ;

Panteleeff, D. ;

Thomas, K. K. ;

Kidoguchi, L. ;

Krows, M. ;

Revall, J. ;

Morrison, S. ;

Haugen, H. ;

Emmanuel-Ogier, M. ;

Ondrejcek, L. ;

Coombs, R. W. ;

Frenkel, L. ;

Hendrix, C. ;

Bumpus, N. N. ;

Bangsberg, D. ;

Haberer, J. E. ;

Stevens, W. S. ;

Lingappa, J. R. ;

Celum, C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (05) :399-410

[4] Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial [J].

Baeten, Jared M. ;

Donnell, Deborah ;

Mugo, Nelly R. ;

Ndase, Patrick ;

Thomas, Katherine K. ;

Campbell, James D. ;

Wangisi, Jonathan ;

Tappero, Jordan W. ;

Bukusi, Elizabeth A. ;

Cohen, Craig R. ;

Katabira, Elly ;

Ronald, Allan ;

Tumwesigye, Elioda ;

Were, Edwin ;

Fife, Kenneth H. ;

Kiarie, James ;

Farquhar, Carey ;

John-Stewart, Grace ;

Kidoguchi, Lara ;

Coombs, Robert W. ;

Hendrix, Craig ;

Marzinke, Mark A. ;

Frenkel, Lisa ;

Haberer, Jessica E. ;

Bangsberg, David ;

Celum, Connie .

LANCET INFECTIOUS DISEASES, 2014, 14 (11) :1055-1064

[5] A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine [J].

Cottrell, Mackenzie L. ;

Yang, Kuo H. ;

Prince, Heather M. A. ;

Sykes, Craig ;

White, Nicole ;

Malone, Stephanie ;

Dellon, Evan S. ;

Madanick, Ryan D. ;

Shaheen, Nicholas J. ;

Hudgens, Michael G. ;

Wulff, Jacob ;

Patterson, Kristine B. ;

Nelson, Julie A. E. ;

Kashuba, Angela D. M. .

JOURNAL OF INFECTIOUS DISEASES, 2016, 214 (01) :55-64

[6] Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial [J].

Delany-Moretlwe, Sinead ;

Hughes, James P. ;

Bock, Peter ;

Ouma, Samuel Gurrion ;

Hunidzarira, Portia ;

Kalonji, Dishiki ;

Kayange, Noel ;

Makhema, Joseph ;

Mandima, Patricia ;

Mathew, Carrie ;

Spooner, Elizabeth ;

Mpendo, Juliet ;

Mukwekwerere, Pamela ;

Mgodi, Nyaradzo ;

Ntege, Patricia Nahirya ;

Nair, Gonasagrie ;

Nakabiito, Clemensia ;

Nuwagaba-Biribonwoha, Harriet ;

Panchia, Ravindre ;

Singh, Nishanta ;

Siziba, Bekezela ;

Farrior, Jennifer ;

Rose, Scott ;

Anderson, Peter L. ;

Eshleman, Susan H. ;

Marzinke, Mark A. ;

Hendrix, Craig W. ;

Beigel-Orme, Stephanie ;

Hosek, Sybil ;

Tolley, Elizabeth ;

Sista, Nirupama ;

Adeyeye, Adeola ;

Rooney, James F. ;

Rinehart, Alex ;

Spreen, William R. ;

Smith, Kimberly ;

Hanscom, Brett ;

Cohen, Myron S. ;

Hosseinipour, Mina C. .

LANCET, 2022, 399 (10337) :1779-1789

[7] Characterization of Human Immunodeficiency Virus (HIV) Infections in Women Who Received Injectable Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention: HPTN 084 [J].

Eshleman, Susan H. ;

Fogel, Jessica M. ;

Piwowar-Manning, Estelle ;

Chau, Gordon ;

Cummings, Vanessa ;

Agyei, Yaw ;

Richardson, Paul ;

Sullivan, Philip ;

Haines, Casey D. ;

Bushman, Lane R. ;

Petropoulos, Christos ;

Persaud, Deborah ;

Kofron, Ryan ;

Hendrix, Craig W. ;

Anderson, Peter L. ;

Farrior, Jennifer ;

Mellors, John ;

Adeyeye, Adeola ;

Rinehart, Alex ;

St Clair, Marty ;

Ford, Susan ;

Rooney, James F. ;

Mathew, Carrie-Anne ;

Hunidzarira, Portia ;

Spooner, Elizabeth ;

Mpendo, Juliet ;

Nair, Gonasagrie ;

Cohen, Myron S. ;

Hughes, James P. ;

Hosseinipour, Mina ;

Hanscom, Brett ;

Delany-Moretlwe, Sinead ;

Marzinke, Mark A. .

JOURNAL OF INFECTIOUS DISEASES, 2022, 225 (10) :1741-1749

[8] Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study [J].

Grant, Robert M. ;

Anderson, Peter L. ;

McMahan, Vanessa ;

Liu, Albert ;

Amico, K. Rivet ;

Mehrotra, Megha ;

Hosek, Sybil ;

Mosquera, Carlos ;

Casapia, Martin ;

Montoya, Orlando ;

Buchbinder, Susan ;

Veloso, Valdilea G. ;

Mayer, Kenneth ;

Chariyalertsak, Suwat ;

Bekker, Linda-Gail ;

Kallas, Esper G. ;

Schechter, Mauro ;

Guanira, Juan ;

Bushman, Lane ;

Burns, David N. ;

Rooney, James F. ;

Glidden, David V. .

LANCET INFECTIOUS DISEASES, 2014, 14 (09) :820-829

[9] Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women [J].

Landovitz, Raphael J. ;

Donnell, Deborah ;

Clement, Meredith E. ;

Hanscom, Brett ;

Cottle, Leslie ;

Coelho, Lara ;

Cabello, Robinson ;

Chariyalertsak, Suwat ;

Dunne, Eileen F. ;

Frank, Ian ;

Gallardo-Cartagena, Jorge A. ;

Gaur, Aditya H. ;

Gonzales, Pedro ;

Tran, Ha V. ;

Hinojosa, Juan C. ;

Kallas, Esper G. ;

Kelley, Colleen F. ;

Losso, Marcelo H. ;

Madruga, J. Valdez ;

Middelkoop, Keren ;

Phanuphak, Nittaya ;

Santos, Breno ;

Sued, Omar ;

Valencia Huamani, Javier ;

Overton, Edgar T. ;

Swaminathan, Shobha ;

del Rio, Carlos ;

Gulick, Roy M. ;

Richardson, Paul ;

Sullivan, Philip ;

Piwowar-Manning, Estelle ;

Marzinke, Mark ;

Hendrix, Craig ;

Li, Maoji ;

Wang, Zhe ;

Marrazzo, Jeanne ;

Daar, Eric ;

Asmelash, Aida ;

Brown, Todd T. ;

Anderson, Peter ;

Eshleman, Susan H. ;

Bryan, Marcus ;

Blanchette, Cheryl ;

Lucas, Jonathan ;

Psaros, Christina ;

Safren, Steven ;

Sugarman, Jeremy ;

Scott, Hyman ;

Eron, Joseph J. ;

Fields, Sheldon D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) :595-608

[10] Characterization of Human Immunodeficiency Virus (HIV) Infection in Cisgender Men and Transgender Women Who Have Sex With Men Receiving Injectable Cabotegravir for HIV Prevention: HPTN 083 [J].

Marzinke, Mark A. ;

Grinsztejn, Beatriz ;

Fogel, Jessica M. ;

Piwowar-Manning, Estelle ;

Li, Maoji ;

Weng, Lei ;

McCauley, Marybeth ;

Cummings, Vanessa ;

Ahmed, Shahnaz ;

Haines, Casey D. ;

Bushman, Lane R. ;

Petropoulos, Christos ;

Persaud, Deborah ;

Adeyeye, Adeola ;

Kofron, Ryan ;

Rinehart, Alex ;

St Clair, Marty ;

Rooney, James F. ;

Pryluka, Daniel ;

Coelho, Lara ;

Gaur, Aditya ;

Middelkoop, Keren ;

Phanuphak, Nittaya ;

Cohen, Myron S. ;

Hendrix, Craig W. ;

Anderson, Peter ;

Hanscom, Brett ;

Donnell, Deborah ;

Landovitz, Raphael J. ;

Eshleman, Susan H. .

JOURNAL OF INFECTIOUS DISEASES, 2021, 224 (09) :1581-1592

← 1 2 →