New 1,2,3-Triazole-Tethered Chalcone Derivatives: Synthesis, Bioevaluation and Computational Study

被引：2

作者：

Kawale, Ramesh A. ^{[1
,2
]}

Akolkar, Hemantkumar N. ^{[3
]}

Shaikh, Mubarak H. ^{[1
]}

Khedkar, Vijay M. ^{[4
]}

Raut, Deepak N. ^{[5
]}

Darekar, Nirmala R. ^{[1
]}

Wable, Jaidip B. ^{[6
]}

Shelke, Sharad N. ^{[1
,7
,8
]}

机构：

[1] Radhabai Kale Mahila Mahavidyalaya, Dept Chem, Ahmednagar, Maharashtra, India

[2] Arts Sci & Commerce Coll Mokhada, Dept Chem, Mokhada, Maharashtra, India

[3] Abasaheb Marathe Arts & New Commerce Sci Coll Raja, Dept Chem, Ratnagiri, Maharashtra, India

[4] Vishwakarma Univ, Sch Pharm, Pune, Maharashtra, India

[5] Amrutvahini Coll Pharm, Sangamner, Maharashtra, India

[6] KJ Somaiya Coll Sci & Commerce, Dept Chem, Mumbai, Maharashtra, India

[7] RBNB Coll, Dept Chem, Shrirampur, Maharashtra, India

[8] Radhabai Kale Mahila Mahavidyalaya, Dept Chem, Ahmednagar 414001, Maharashtra, India

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2024年 / 44卷 / 09期

关键词：

Click chemistry; 1,2,3-triazoles; chalcone; anti-inflammatory; antioxidant; TRIAZOLE-LINKED CHALCONE; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ANTIOXIDANT; DESIGN;

D O I：

10.1080/10406638.2023.2276239

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In search of new active molecules, a small focused library of novel 1,2,3-triazoles based chalcone derivatives has been efficiently prepared via the click chemistry approach. All the synthesized compounds were characterized with the help of IR, H-1 NMR, C-13 NMR and mass spectroscopic techniques. The synthesized novel 1,2,3-triazoles based chalcone derivatives evaluated for their anti-inflammatory and antioxidant activity. Furthermore, molecular modeling study could support these outcomes by demonstrating very good binding affinities at the active site of the cyclooxygenase 2 (COX-2) iterating the potential of this scaffold for further optimization.

引用

页码：6232 / 6247

页数：16

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