Anti-Inflammatory Effects of Peripheral Dopamine

被引：10

作者：

Moore, Shaun C. ^{[1
]}

de Castro, Pedro A. S. Vaz ^{[1
]}

Yaqub, Daniel ^{[1
]}

Jose, Pedro A. ^{[1
]}

Armando, Ines ^{[1
]}

机构：

[1] George Washington Univ, Sch Med & Hlth Sci, Div Kidney Dis & Hypertens, Dept Med, Washington, DC 20037 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 18期

关键词：

immune cells; signaling pathways; kidney; mesenteric organs; pro-inflammatory factors; D2 RECEPTOR GENE; OXYGEN SPECIES PRODUCTION; LOWERS BLOOD-PRESSURE; ACUTE KIDNEY INJURY; ACUTE LIVER-INJURY; FACTOR-KAPPA-B; OXIDATIVE STRESS; C957T POLYMORPHISM; D-2; RECEPTOR; LIPOPOLYSACCHARIDE/D-GALACTOSAMINE;

D O I：

10.3390/ijms241813816

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dopamine is synthesized in the nervous system where it acts as a neurotransmitter. Dopamine is also synthesized in a number of peripheral organs as well as in several types of cells and has organ-specific functions and, as demonstrated more recently, is involved in the regulation of the immune response and inflammatory reaction. In particular, the renal dopaminergic system is very important in the regulation of sodium transport and blood pressure and is particularly sensitive to stimuli that cause oxidative stress and inflammation. This review is focused on how dopamine is synthesized in organs and tissues and the mechanisms by which dopamine and its receptors exert their effects on the inflammatory response.

引用

页数：21

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