Prevalence of Carbapenemases in Carbapenem-Resistant Acinetobacter baumannii Isolates from the Kingdom of Bahrain

被引:10
作者
Al-Rashed, Nouf [1 ]
Bindayna, Khalid M. [1 ]
Shahid, Mohammad [1 ]
Saeed, Nermin Kamal [2 ]
Darwish, Abdullah [3 ]
Joji, Ronni Mol [1 ]
Al-Mahmeed, Ali [1 ]
机构
[1] Arabian Gulf Univ, Coll Med & Med Sci, Dept Microbiol Immunol & Infect Dis, POB 26671, Manama, Bahrain
[2] Al Salmaniya Med Complex, Dept Pathol, Microbiol Sect, POB 12, Manama, Bahrain
[3] Bahrain Def Force Hosp, Dept Pathol, Microbiol Sect, POB 28743, West Riffa, Bahrain
来源
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 07期
关键词
Acinetobacter baumannii; carbapenemases; OXA; KPC; NDM; IMP; VIM; MOLECULAR EPIDEMIOLOGY;
D O I
10.3390/antibiotics12071198
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Acinetobacter baumannii is regarded as a significant cause of death in hospitals. The WHO recently added carbapenem-resistant Acinetobacter baumannii (CRAB) to its global pathogen priority list. There is a dearth of information on CRAB from our region. Methods: Fifty CRAB isolates were collected from four main hospitals in Bahrain for this study. Bacterial identification and antibiotic susceptibility tests were carried out using the BD Phoenix (TM) and VITEK-2 compact, respectively. Using conventional PCR, these isolates were further screened for carbapenem resistance markers (bla(OXA-51), bla(OXA-23), bla(OXA-24), bla(OXA-40), bla(IMP) ,bla(NDM), bla(VIM), and bla(KPC)). Results: All of the isolates were resistant to imipenem (100%), meropenem (98%), and cephalosporins (96-98%), followed by other commonly used antibiotics. All these isolates were least resistant to gentamicin (64%). The detection of resistance determinants showed that the majority harbored bla(OXA-51) (100%) and blaIMP (94%), followed by bla(OXA-23) (82%), bla(OXA-24) (46%), bla(OXA-40) (14%), bla(NDM) (6%), bla(VIM) (2%), and bla(KPC) (2%). Conclusion: The study isolates showed a high level of antibiotic resistance. Class D carbapenemases were more prevalent in our CRAB isolate collection. The resistance genes were found in various combinations. This study emphasizes the importance of strengthening surveillance and stringent infection control measures in clinical settings to prevent the emergence and further spread of such isolates.
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页数:10
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