Deoxyestrone-based lipofection agents with solution- and solid-state emission properties

被引：2
作者：
Huber, Alexander [1 ,2 ]
Koch, Johannes [3 ]
Rudolph, Kevin [1 ,2 ]
Hoeing, Alexander [4 ]
Rizzo, Fabio [5 ,6 ]
Knauer, Shirley K. [4 ]
Voskuhl, Jens [1 ,2 ]
机构：
[1] Univ Duisburg Essen, Fac Chem Organ Chem, Ctr Med Biotechnol ZMB, Univ str 7, D-45117 Essen, Germany
[2] Univ Duisburg Essen, Ctr NanoIntegrat CENIDE, Univ str 7, D-45117 Essen, Germany
[3] Univ Duisburg Essen, Ctr Med Biotechnol ZMB, Univ str 2, D-45141 Essen, Germany
[4] Univ Duisburg Essen, Ctr Med Biotechnol ZMB, Dept Mol Biol 2, Univ str 2, D-45141 Essen, Germany
[5] Westfal Wilhelms Univ Munster, Ctr Soft Nanosci SoN, Busso Peus Str 10, D-48149 Munster, Germany
[6] Natl Res Council CNR, Inst Chem Sci & Technol G Natta SCITEC, Via G Fantoli 16-15, I-20138 Milan, Italy
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 28期
关键词：
EFFICIENT VECTORS; NONVIRAL VECTORS; CATIONIC LIPIDS; TRANSFECTION; FLUORESCENCE; REVEALS; DESIGN;
D O I：
10.1039/d3ob00656e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this contribution, three deoxyestrone-based emissive lipofection agents are reported. Because of a centrally incorporated terephthalonitrile motif, these ligands can be classified as solution and solid-state emitters (SSSEs). With the attachment of tobramycin, these amphiphilic structures are able to form lipoplexes, mediating gene transfection of HeLa and HEK 293T cells.
引用
收藏
页码：5762 / 5767
页数：6
相关论文
共 38 条
  • [1] Aminoglycosides: From Antibiotics to Building Blocks for the Synthesis and Development of Gene Delivery Vehicles
    Bellucci, Maria Cristina
    Volonterio, Alessandro
    [J]. ANTIBIOTICS-BASEL, 2020, 9 (08): : 1 - 29
  • [2] Aminoglycoside-derived cationic lipids as efficient vectors for gene transfection in vitro and in vivo
    Belmont, P
    Aissaoui, A
    Hauchecorne, M
    Oudrhiri, N
    Petit, L
    Vigneron, JP
    Lehn, JM
    Lehn, P
    [J]. JOURNAL OF GENE MEDICINE, 2002, 4 (05) : 517 - 526
  • [3] Dual-State Emission (DSE) in Organic Fluorophores: Design and Applications
    Belmonte-Vazquez, Jose L.
    Amador-Sanchez, Yoarhy A.
    Rodriguez-Cortes, Lizbeth A.
    Rodriguez-Molina, Braulio
    [J]. CHEMISTRY OF MATERIALS, 2021, 33 (18) : 7160 - 7184
  • [4] Design, synthesis, and antibacterial activities of neomycin-lipid conjugates: Polycationic lipids with potent gram-positive activity
    Bera, Smritilekha
    Zhanel, George G.
    Schweizer, Frank
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (19) : 6160 - 6164
  • [5] Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery
    Buck, Jonas
    Grossen, Philip
    Cullis, Pieter R.
    Huwyler, Jorg
    Witzigmann, Dominik
    [J]. ACS NANO, 2019, 13 (04) : 3754 - 3782
  • [6] A monomeric red fluorescent protein
    Campbell, RE
    Tour, O
    Palmer, AE
    Steinbach, PA
    Baird, GS
    Zacharias, DA
    Tsien, RY
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) : 7877 - 7882
  • [7] Conjugation-Induced Rigidity in Twisting Molecules: Filling the Gap Between Aggregation-Caused Quenching and Aggregation-Induced Emission
    Chen, Gan
    Li, Wenbo
    Zhou, Tianru
    Peng, Qian
    Zhai, Di
    Li, Hongxiang
    Yuan, Wang Zhang
    Zhang, Yongming
    Tang, Ben Zhong
    [J]. ADVANCED MATERIALS, 2015, 27 (30) : 4496 - 4501
  • [8] Corbett Kizzmekia S, 2020, Nature, V586, P567, DOI [10.1101/2020.06.11.145920, 10.1038/s41586-020-2622-0]
  • [9] In-Culture Cross-Linking of Bacterial Cells Reveals Large-Scale Dynamic Protein-Protein Interactions at the Peptide Level
    de Jong, Luitzen
    de Koning, Edward A.
    Roseboom, Winfried
    Buncherd, Hansuk
    Wanner, Martin J.
    Dapic, Irena
    Jansen, Petra J.
    van Maarseveen, Jan H.
    Corthals, Garry L.
    Lewis, Peter J.
    Hamoen, Leendert W.
    de Koster, Chris G.
    [J]. JOURNAL OF PROTEOME RESEARCH, 2017, 16 (07) : 2457 - 2471
  • [10] Dobretsov G. E., 2014, Biofizika, V59, P231
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