Implant vs. autologous tissue-based breast reconstruction: A systematic review and meta-analysis of the studies comparing surgical approaches in 55,455 patients

Background: The choice of reconstruction type is of utmost importance in treating breast cancer. There are two major reconstructive pathways in this group of patients: autol-ogous breast reconstruction (ABR) and implant-based breast reconstruction (IBR). The aim of this systematic review and meta-analysis was to assess and compare IBR vs. ABR.Methods: A review of studies reporting the differences between the procedures was per-formed. The MEDLINE/PubMed, ScienceDirect, EMBASE, BIOSIS, SciELO, Scopus, and Web of Science databases were thoroughly searched in September 2021. The data concerning group characteristics, BREAST-Q scores, complication rates, length of stay (LOS), and costs were ex-tracted. The Cochrane risk-of-bias tool was used for randomized studies, while Newcastle- Ottawa Quality Assessment for Cohort Studies was used for other types of research. Results: Our meta-analysis included 32 studies ( n = 55,455). We observed significantly better outcomes following ABR when it comes to esthetic satisfaction (mean difference [MD]-8.51; 95% confidence interval [CI]-10.70,-6.33; p < 0.001) and satisfaction with the entire recon-structive treatment (MD-6.56; 95% CI-9.97,-3.14; p < 0.001). Both methods appeared to be comparable in terms of safety, while the complication rates varied insignificantly between the groups (odds ratio [OR] 1.06; 95% CI 0.71, 1.59; p = 0.76). ABR seems to be correlated with sig-nificantly higher costs (standard mean difference [SMD]-0.69; 95% CI-1.21,-0.17; p = 0.010).Conclusions: The results obtained from this evidence-based study will improve the understand-ing of the different clinical pathways that patients can be assigned to. The study emphasized the advantages and disadvantages of both methods.(c) 2022 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by El-sevier Ltd. All rights reserved.