Electrochemical Hydroalkylation of Quinoxalin-2(1H)-ones with Alkyl Halides

被引：5
|
作者：
Qiu, Zhihong [1 ]
Huang, Xianting [1 ]
Wu, Jintao [1 ]
Liu, Zhong-Quan [1 ]
机构：
[1] Nanjing Univ Chinese Med, Coll Pharm, Jiangsu Collaborat Innovat Ctr Chinese Med Resourc, Nanjing 210023, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 03期
基金：
中国国家自然科学基金;
关键词：
radical reactions; quinoxalin-2(1H)-ones; electrochemistry; alkylation; allylation; ARYLATION; TRIFLUOROMETHYLATION; HETEROCYCLES; ACYLATION; THIOLS;
D O I：
10.1002/adsc.202201241
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We reported herein an electrochemically reductive alkylation, allylation and propargylation of quinoxalin-2(1H)-ones with haloalkanes. In an undivided cell, treatment of quinoxalin-2(1H)-ones and alkyl halides with constant current, a wide range of 3-alkylated-3,4-dihydroquinoxalin-2(1H)-one and its derivatives can be isolated in 25-87% yields.
引用
收藏
页码：318 / 322
页数：5
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