Circulating tumor DNA validity and potential uses in metastatic breast cancer

被引：19

作者：

Amato, Ottavia ^{[1
,2
]}

Giannopoulou, Nefeli ^{[3
]}

Ignatiadis, Michail ^{[4
,5
]}

机构：

[1] Univ Padua, Dept Surg Oncol & Gastroenterol DISCOG, Padua, Italy

[2] Ist Oncol Veneto IOV IRCCS, Med Oncol 2, Padua, Italy

[3] Univ Nicosia, Med Sch, Dept Basic & Clin Sci, Nicosia, Cyprus

[4] Univ Libre Bruxelles, Inst Jules Bordet, Breast Med Oncol Clin, Brussels, Belgium

[5] Univ Libre Bruxelles, Brussels, Belgium

来源：

NPJ BREAST CANCER | 2024年 / 10卷 / 01期

关键词：

POSITIVE SOLID TUMORS; CELL-FREE DNA; BRCA2 REVERSION MUTATIONS; ESR1; MUTATIONS; PHASE; 1/2; THERAPY; PALBOCICLIB; RESISTANCE; GUIDELINE; ALPELISIB;

D O I：

10.1038/s41523-024-00626-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Following the first characterization of circulating tumor DNA (ctDNA) in the 1990s, recent advances led to its introduction in the clinics. At present, the European Society Of Medical Oncology (ESMO) recommendations endorse ctDNA testing in routine clinical practice for tumor genotyping to direct molecularly targeted therapies in patients with metastatic cancer. In studies on metastatic breast cancer, ctDNA has been utilized for treatment tailoring, tracking mechanisms of drug resistance, and for predicting disease response before imaging. We review the available evidence regarding ctDNA applications in metastatic breast cancer.

引用

页数：7

共 87 条

[61] Baseline Mutations and ctDNA Dynamics as Prognostic and Predictive Factors in ER-Positive/HER2-Negative Metastatic Breast Cancer Patients [J].

Pascual, Javier ;

Gil-Gil, Miguel ;

Proszek, Paula ;

Zielinski, Christoph ;

Reay, Alistair ;

Ruiz-Borrego, Manuel ;

Cutts, Rosalind ;

Ciruelos Gil, Eva M. ;

Feber, Andrew ;

Munoz-Mateu, Montserrat ;

Swift, Claire ;

Bermejo, Begona ;

Herranz, Jesus ;

Margeli Vila, Mireia ;

Anton, Antonio ;

Kahan, Zsuzsanna ;

Csoeszi, Tibor ;

Liu, Yuan ;

Fernandez-Garcia, Daniel ;

Garcia-Murillas, Isaac ;

Hubank, Michael ;

Turner, Nicholas C. ;

Martin, Miguel .

CLINICAL CANCER RESEARCH, 2023, 29 (20) :4166-4177

[62] Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer [J].

Prat, Aleix ;

Braso-Maristany, Fara ;

Martinez-Saez, Olga ;

Sanfeliu, Esther ;

Xia, Youli ;

Bellet, Meritxell ;

Galvan, Patricia ;

Martinez, Debora ;

Pascual, Tomas ;

Marin-Aguilera, Mercedes ;

Rodriguez, Anna ;

Chic, Nuria ;

Adamo, Barbara ;

Pare, Laia ;

Vidal, Maria ;

Margeli, Mireia ;

Ballana, Ester ;

Gomez-Rey, Marina ;

Oliveira, Mafalda ;

Felip, Eudald ;

Matito, Judit ;

Sanchez-Bayona, Rodrigo ;

Sunol, Anna ;

Saura, Cristina ;

Ciruelos, Eva ;

Tolosa, Pablo ;

Munoz, Montserrat ;

Gonzalez-Farre, Blanca ;

Villagrasa, Patricia ;

Parker, Joel S. ;

Perou, Charles M. ;

Vivancos, Ana .

NATURE COMMUNICATIONS, 2023, 14 (01)

[63] Analysis of Circulating Cell-Free DnA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors [J].

Quigley, David ;

Alumkal, Joshi J. ;

Wyatt, Alexander W. ;

Kothari, Vishal ;

Foye, Adam ;

Lloyd, Paul ;

Aggarwal, Rahul ;

Kim, Won ;

Lu, Eric ;

Schwartzman, Jacob ;

Beja, Kevin ;

Annala, Matti ;

Das, Rajdeep ;

Diolaiti, Morgan ;

Pritchard, Colin ;

Thomas, George ;

Tomlins, Scott ;

Knudsen, Karen ;

Lord, Christopher J. ;

Ryan, Charles ;

Youngren, Jack ;

Beer, Tomasz M. ;

Ashworth, Alan ;

Small, Eric J. ;

Feng, Felix Y. .

CANCER DISCOVERY, 2017, 7 (09) :999-1005

[64] High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants [J].

Razavi, Pedram ;

Li, Bob T. ;

Brown, David N. ;

Jung, Byoungsok ;

Hubbell, Earl ;

Shen, Ronglai ;

Abida, Wassim ;

Juluru, Krishna ;

De Bruijn, Ino ;

Hou, Chenlu ;

Venn, Oliver ;

Lim, Raymond ;

Anand, Aseem ;

Maddala, Tara ;

Gnerre, Sante ;

Satya, Ravi Vijaya ;

Liu, Qinwen ;

Shen, Ling ;

Eattock, Nicholas ;

Yue, Jeanne ;

Blocker, Alexander W. ;

Lee, Mark ;

Sehnert, Amy ;

Xu, Hui ;

Hall, Megan P. ;

Santiago-Zayas, Angie ;

Novotny, William F. ;

Isbell, James M. ;

Rusch, Valerie W. ;

Plitas, George ;

Heerdt, Alexandra S. ;

Ladanyi, Marc ;

Hyman, David M. ;

Jones, David R. ;

Morrow, Monica ;

Riely, Gregory J. ;

Scher, Howard I. ;

Rudin, Charles M. ;

Robson, Mark E. ;

Diaz, Luis A., Jr. ;

Solit, David B. ;

Aravanis, Alexander M. ;

Reis-Filho, Jorge S. .

NATURE MEDICINE, 2019, 25 (12) :1928-+

[65] Prognostic value of plasma circulating tumor DNA fraction across four common cancer types: a real-world outcomes study [J].

Reichert, Z. R. ;

Morgan, T. M. ;

Li, G. ;

Castellanos, E. ;

Snow, T. ;

Dall'Olio, F. G. ;

Madison, R. W. ;

Fine, A. D. ;

Oxnard, G. R. ;

Graf, R. P. ;

Stover, D. G. .

ANNALS OF ONCOLOGY, 2023, 34 (01) :111-120

[66] OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer [J].

Robson, M. E. ;

Tung, N. ;

Conte, P. ;

Im, S-A ;

Senkus, E. ;

Xu, B. ;

Masuda, N. ;

Delaloge, S. ;

Li, W. ;

Armstrong, A. ;

Wu, W. ;

Goessl, C. ;

Runswick, S. ;

Domchek, S. M. .

ANNALS OF ONCOLOGY, 2019, 30 (04) :558-566

[67] NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types [J].

Rolfo, Christian ;

Drilon, Alexander ;

Hong, David ;

McCoach, Caroline ;

Dowlati, Afshin ;

Lin, Jessica J. ;

Russo, Alessandro ;

Schram, Alison M. ;

Liu, Stephen, V ;

Nieva, Jorge J. ;

Nguyen, Timmy ;

Eshaghian, Shahrooz ;

Morse, Michael ;

Gettinger, Scott ;

Mobayed, Mohammad ;

Goldberg, Sarah ;

Araujo-Mino, Emilio ;

Vidula, Neelima ;

Bardia, Aditya ;

Subramanian, Janakiraman ;

Sashital, Deepa ;

Stinchcombe, Thomas ;

Kiedrowski, Lesli ;

Price, Kristin ;

Gandara, David R. .

BRITISH JOURNAL OF CANCER, 2022, 126 (03) :514-520

[68] Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma [J].

Rugo, Hope S. ;

Raskina, Kira ;

Schrock, Alexa B. ;

Madison, Russell W. ;

Graf, Ryon P. ;

Sokol, Ethan S. ;

Sivakumar, Smruthy ;

Lee, Jessica K. ;

Fisher, Virginia ;

Oxnard, Geoffrey R. ;

Tukachinsky, Hanna .

CLINICAL CANCER RESEARCH, 2023, 29 (06) :1056-1067

[69] Alpelisib Monotherapy for PI3K-Altered, Pretreated Advanced Breast Cancer: A Phase II Study [J].

Savas, Peter ;

Lo, Louisa L. ;

Luen, Stephen J. ;

Blackley, Elizabeth F. ;

Callahan, Jason ;

Moodie, Kate ;

van Geelen, Courtney T. ;

Ko, Yi-An ;

Weng, Chen-Fang ;

Wein, Lironne ;

Silva, Maria Joao ;

Bujak, Andjelija Zivanovic ;

Yeung, Miriam M. ;

Ftouni, Sarah ;

Hicks, Rodney J. ;

Francis, Prudence A. ;

Lee, Chee Khoon ;

Dawson, Sarah-Jane ;

Loi, Sherene .

CANCER DISCOVERY, 2022, 12 (09) :2058-2073

[70] Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer [J].

Schiavon, Gaia ;

Hrebien, Sarah ;

Garcia-Murillas, Isaac ;

Cutts, Rosalind J. ;

Pearson, Alex ;

Tarazona, Noelia ;

Fenwick, Kerry ;

Kozarewa, Iwanka ;

Lopez-Knowles, Elena ;

Ribas, Ricardo ;

Nerurkar, Ashutosh ;

Osin, Peter ;

Chandarlapaty, Sarat ;

Martin, Lesley-Ann ;

Dowsett, Mitch ;

Smith, Ian E. ;

Turner, Nicholas C. .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (313)

← 1 2 3 4 5 6 7 8 9 →