Circulating tumor DNA validity and potential uses in metastatic breast cancer

被引：19

作者：

Amato, Ottavia ^{[1
,2
]}

Giannopoulou, Nefeli ^{[3
]}

Ignatiadis, Michail ^{[4
,5
]}

机构：

[1] Univ Padua, Dept Surg Oncol & Gastroenterol DISCOG, Padua, Italy

[2] Ist Oncol Veneto IOV IRCCS, Med Oncol 2, Padua, Italy

[3] Univ Nicosia, Med Sch, Dept Basic & Clin Sci, Nicosia, Cyprus

[4] Univ Libre Bruxelles, Inst Jules Bordet, Breast Med Oncol Clin, Brussels, Belgium

[5] Univ Libre Bruxelles, Brussels, Belgium

来源：

NPJ BREAST CANCER | 2024年 / 10卷 / 01期

关键词：

POSITIVE SOLID TUMORS; CELL-FREE DNA; BRCA2 REVERSION MUTATIONS; ESR1; MUTATIONS; PHASE; 1/2; THERAPY; PALBOCICLIB; RESISTANCE; GUIDELINE; ALPELISIB;

D O I：

10.1038/s41523-024-00626-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Following the first characterization of circulating tumor DNA (ctDNA) in the 1990s, recent advances led to its introduction in the clinics. At present, the European Society Of Medical Oncology (ESMO) recommendations endorse ctDNA testing in routine clinical practice for tumor genotyping to direct molecularly targeted therapies in patients with metastatic cancer. In studies on metastatic breast cancer, ctDNA has been utilized for treatment tailoring, tracking mechanisms of drug resistance, and for predicting disease response before imaging. We review the available evidence regarding ctDNA applications in metastatic breast cancer.

引用

页数：7

共 87 条

[1] Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative [J].

Aftimos, Philippe ;

Oliveira, Mafalda ;

Irrthum, Alexandre ;

Fumagalli, Debora ;

Sotiriou, Christos ;

Gal-Yam, Einav Nili ;

Robson, Mark E. ;

Ndozeng, Justin ;

Di Leo, Angelo ;

Ciruelos, Eva M. ;

de Azambuja, Evandro ;

Viale, Giuseppe ;

Scheepers, Elsemieke D. ;

Curigliano, Giuseppe ;

Bliss, Judith M. ;

Reis-Filho, Jorge S. ;

Colleoni, Marco ;

Balic, Marija ;

Cardoso, Fatima ;

Albanell, Joan ;

Duhem, Caroline ;

Marreaud, Sandrine ;

Romagnoli, Dario ;

Rojas, Beatriz ;

Gombos, Andrea ;

Wildiers, Hans ;

Guerrero-Zotano, Angel ;

Hall, Peter ;

Bonetti, Andrea ;

Larsson, Karolina Fs ;

Degiorgis, Martina ;

Khodaverdi, Silvia ;

Greil, Richard ;

Sverrisdottir, Asgerdur ;

Paoli, Marta ;

Seyll, Ethel ;

Loibl, Sibylle ;

Linderholm, Barbro ;

Zoppoli, Gabriele ;

Davidson, Nancy E. ;

Johannsson, Oskar Th ;

Bedard, Philippe L. ;

Loi, Sherene ;

Knox, Susan ;

Cameron, David A. ;

Harbeck, Nadia ;

Montoya, Maite Lasa ;

Brandao, Mariana ;

Vingiani, Andrea ;

Caballero, Carmela .

CANCER DISCOVERY, 2021, 11 (11) :2796-2811

[2] ctDNA as a predictive biomarker in advanced breast cancer: Lessons from the MONALEESA studies [J].

Agostinetto, E. ;

Ignatiadis, M. .

ANNALS OF ONCOLOGY, 2023, 34 (11) :955-959

[3] Palbociclib Rechallenge for Hormone Receptor- Positive/HER-Negative Advanced Breast Cancer: Findings from the Phase II BioPER Trial [J].

Albanell, Joan ;

Manuel Perez-Garcia, Jose ;

Gil-Gil, Miguel ;

Curigliano, Giuseppe ;

Ruiz-Borrego, Manuel ;

Comerma, Laura ;

Gibert, Joan ;

Bellet, Meritxell ;

Bermejo, Begona ;

Calvo, Lourdes ;

de la Haba, Juan ;

Espinosa, Enrique ;

Marco Minisini, Alessandro ;

Quiroga, Vanesa ;

Santaballa Bertran, Ana ;

Mina, Leonardo ;

Bellosillo, Beatriz ;

Rojo, Federico ;

Menendez, Silvia ;

Sampayo-Cordero, Miguel ;

Popa, Crina ;

Malfettone, Andrea ;

Cortes, Javier ;

Llombart-Cussac, Antonio .

CLINICAL CANCER RESEARCH, 2022, 29 (01) :67-80

[4] Pembrolizumab in Patients With Metastatic Breast Cancer With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study [J].

Alva, Ajjai S. ;

Mangat, Pam K. ;

Garrett-Mayer, Elizabeth ;

Halabi, Susan ;

Hansra, Damien ;

Calfa, Carmen J. ;

Khalil, Maged F. ;

Ahn, Eugene R. ;

Cannon, Timothy L. ;

Crilley, Pamela ;

Fisher, Julie G. ;

Haslem, Derrick S. ;

Shrestha, Sagun ;

Antonelli, Kaitlyn R. ;

Butler, Nicole L. ;

Warren, Sasha L. ;

Rygiel, Andrew L. ;

Ranasinghe, Shamika ;

Bruinooge, Suanna S. ;

Schilsky, Richard L. .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (22) :2443-+

[5] Pooled ctDNA analysis of MONALEESA phase III advanced breast cancer trials [J].

Andre, F. ;

Su, F. ;

Solovieff, N. ;

Hortobagyi, G. ;

Chia, S. ;

Neven, P. ;

Bardia, A. ;

Tripathy, D. ;

Lu, Y. -s. ;

Lteif, A. ;

Taran, T. ;

Babbar, N. ;

Slamon, D. ;

Arteaga, C. L. .

ANNALS OF ONCOLOGY, 2023, 34 (11) :1003-1014

[6] Alpelisib plus fulvestrant for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2enegative advanced breast cancer: final overall survival results from SOLAR-1 [J].

Andre, F. ;

Ciruelos, E. M. ;

Juric, D. ;

Loibl, S. ;

Campone, M. ;

Mayer, I. A. ;

Rubovszky, G. ;

Yamashita, T. ;

Kaufman, B. ;

Lu, Y-S ;

Inoue, K. ;

Papai, Z. ;

Takahashi, M. ;

Ghaznawi, F. ;

Mills, D. ;

Kaper, M. ;

Miller, M. ;

Conte, P. F. ;

Iwata, H. ;

Rugo, H. S. .

ANNALS OF ONCOLOGY, 2021, 32 (02) :208-217

[7] Genomics to select treatment for patients with metastatic breast cancer [J].

Andre, Fabrice ;

Filleron, Thomas ;

Kamal, Maud ;

Mosele, Fernanda ;

Arnedos, Monica ;

Dalenc, Florence ;

Sablin, Marie-Paule ;

Campone, Mario ;

Bonnefoi, Herve ;

Lefeuvre-Plesse, Claudia ;

Jacot, William ;

Coussy, Florence ;

Ferrero, Jean-Marc ;

Emile, George ;

Mouret-Reynier, Marie-Ange ;

Thery, Jean-Christophe ;

Isambert, Nicolas ;

Mege, Alice ;

Barthelemy, Philippe ;

You, Benoit ;

Hajjaji, Nawale ;

Lacroix, Ludovic ;

Rouleau, Etienne ;

Tran-Dien, Alicia ;

Boyault, Sandrine ;

Attignon, Valery ;

Gestraud, Pierre ;

Servant, Nicolas ;

Le Tourneau, Christophe ;

Cherif, Linda Larbi ;

Soubeyran, Isabelle ;

Montemurro, Filippo ;

Morel, Alain ;

Lusque, Amelie ;

Jimenez, Marta ;

Jacquet, Alexandra ;

Goncalves, Anthony ;

Bachelot, Thomas ;

Bieche, Ivan .

NATURE, 2022, 610 (7931) :343-+

[8] Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer [J].

Andre, Fabrice ;

Ciruelos, Eva ;

Rubovszky, Gabor ;

Campone, Mario ;

Loibl, Sibylle ;

Rugo, Hope S. ;

Iwata, Hiroji ;

Conte, Pierfranco ;

Mayer, Ingrid A. ;

Kaufman, Bella ;

Yamashita, Toshinari ;

Lu, Yen-Shen ;

Inoue, Kenichi ;

Takahashi, Masato ;

Papai, Zsuzsanna ;

Longin, Anne-Sophie ;

Mills, David ;

Wilke, Celine ;

Hirawat, Samit ;

Juric, Dejan .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (20) :1929-1940

[9] Oncology phase I trial design and conduct: time for a change- MDICT Guidelines 2022 [J].

Araujo, D. ;

Greystoke, A. ;

Bates, S. ;

Bayle, A. ;

Calvo, E. ;

Castelo-Branco, L. ;

de Bono, J. ;

Drilon, A. ;

Garralda, E. ;

Ivy, P. ;

Kholmanskikh, O. ;

Melero, I. ;

Pentheroudakis, G. ;

Petrie, J. ;

Plummer, R. ;

Ponce, S. ;

Postel-Vinay, S. ;

Siu, L. ;

Spreafico, A. ;

Stathis, A. ;

Steeghs, N. ;

Yap, C. ;

Yap, T. A. ;

Ratain, M. ;

Seymour, L. .

ANNALS OF ONCOLOGY, 2023, 34 (01) :48-60

[10] Precision medicine for metastatic breast cancer-limitations and solutions [J].

Arnedos, Monica ;

Vicier, Cecile ;

Loi, Sherene ;

Lefebvre, Celine ;

Michiels, Stefan ;

Bonnefoi, Herve ;

Andre, Fabrice .

NATURE REVIEWS CLINICAL ONCOLOGY, 2015, 12 (12) :693-704

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