Biosensors to detect low-density lipoprotein and oxidized low-density lipoprotein in cardiovascular disease

被引：2

作者：

Ranjbari, Sara ^{[1
]}

Ritchie, Leona A. ^{[2
,3
]}

Arefinia, Reza ^{[1
]}

Kesharwani, Prashant ^{[4
]}

Sahebkar, Amirhossein ^{[5
,6
]}

机构：

[1] Ferdowsi Univ Mashhad, Fac Engn, Chem Engn Dept, Mashhad, Iran

[2] Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Liverpool, England

[3] Liverpool Heart & Chest Hosp, Liverpool, England

[4] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India

[5] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran

来源：

SENSORS AND ACTUATORS A-PHYSICAL | 2024年 / 365卷

关键词：

Cardiovascular disease; LDL; Ox-LDL; Detection; Biosensors; Atherosclerosis; Lipids; FREE ELECTROCHEMICAL IMMUNOSENSOR; LABEL-FREE; MASS-SPECTROMETRY; ENDOTHELIAL DYSFUNCTION; OPTICAL BIOSENSORS; OXIDATIVE STRESS; SHEAR-STRESS; CHOLESTEROL; LDL; SENSOR;

D O I：

10.1016/j.sna.2023.114841

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Cardiovascular disease (CVD) is the main reason for death worldwide, with atherosclerotic disease being recognized as the most prevalent underlying cause. Various studies have linked low-density lipoproteins (LDLs) and oxidized LDLs (ox-LDLs) to atherosclerosis. Early detection of LDL and ox-LDL using biosensors can support early intervention to prevent CVD or improve management. Studies on LDL/ox-LDL biosensors focus on decreasing detection time and developing new detection methods. Techniques such as quartz crystal microbalance, surface plasmon resonance, and electrochemical sensors are powerful tools that enable early and accurate detection. As a result, this technology has the potential to change how cardiovascular disorders are detected and treated completely. The objective of this review is to provide an overview of the role of ox-LDL in atherosclerosis development and the different LDL/ox-LDL biosensor types in the context of their linear range, detection capability, and possible medical applications.

引用

页数：12

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