Cartilage organoids and osteoarthritis research: a narrative review

被引：12

作者：

Zeng, Daofu ^{[1
,2
]}

Chen, Yeping ^{[2
]}

Liao, Zhidong ^{[1
]}

Wei, Guizheng ^{[2
]}

Huang, Xiajie ^{[1
]}

Liang, Rongyuan ^{[2
]}

Lu, William W. ^{[3
]}

Yi, Dan ^{[4
,5
]}

Chen, Yan ^{[1
,2
]}

机构：

[1] Guangxi Med Univ, Collaborat Innovat Ctr Regenerat Med & Med BioReso, Nanning, Guangxi, Peoples R China

[2] Guangxi Med Univ, Dept Bone & Joint Surg, Affiliated Hosp 1, Nanning, Guangxi, Peoples R China

[3] Univ Hong Kong, Dept Orthoped & Traumatol, Pokfulam, Hong Kong, Peoples R China

[4] Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp Aided Drug Discovery, Shenzhen, Peoples R China

[5] Chinese Acad Sci, Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2023年 / 11卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

organoids; cartilage organoids; osteoarthritis; disease model; regeneration and repair; PLURIPOTENT STEM-CELLS; IN-VITRO; MODELING DEVELOPMENT; TISSUE; DIFFERENTIATION; GENERATION; MATRIGEL; THERAPY; LIVER; KNEE;

D O I：

10.3389/fbioe.2023.1278692

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Osteoarthritis (OA) is one of the most common degenerative joint diseases, significantly impacting individuals and society. With the acceleration of global aging, the incidence of OA is increasing. The pathogenesis of osteoarthritis is not fully understood, and there is no effective way to alleviate the progression of osteoarthritis. Therefore, it is necessary to develop new disease models and seek new treatments for OA. Cartilage organoids are three-dimensional tissue masses that can simulate organ structure and physiological function and play an important role in disease modeling, drug screening, and regenerative medicine. This review will briefly analyze the research progress of OA, focusing on the construction and current development of cartilage organoids, and then describe the application of cartilage organoids in OA modeling, drug screening, and regeneration and repair of cartilage and bone defects. Finally, some challenges and prospects in the development of cartilaginous organoids are discussed.

引用

页数：11

共 107 条

[11]

2-F

[12] Directed differentiation of human embryonic stem cells into functional hepatic cells [J].

Cai, Jun ;

Zhao, Yang ;

Liu, Yanxia ;

Ye, Fei ;

Song, Zhihua ;

Qin, Han ;

Meng, Sha ;

Chen, Yuezhou ;

Zhou, Rudan ;

Song, Xijun ;

Guo, Yushan ;

Ding, Mingxiao ;

Deng, Hongkui .

HEPATOLOGY, 2007, 45 (05) :1229-1239

[13] Arthritic Periosteal Tissue From Joint Replacement Surgery: A Novel, Autologous Source of Stem Cells [J].

Chang, Hana ;

Docheva, Denitsa ;

Knothe, Ulf R. ;

Tate, Melissa L. Knothe .

STEM CELLS TRANSLATIONAL MEDICINE, 2014, 3 (03) :308-317

[14] Modeling Development and Disease with Organoids [J].

Clevers, Hans .

CELL, 2016, 165 (07) :1586-1597

[15] Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis [J].

Coll, Mar ;

Perea, Luis ;

Boon, Ruben ;

Leite, Sofia B. ;

Vallverdu, Julia ;

Mannaerts, Inge ;

Smout, Ayla ;

El Taghdouini, Adil ;

Blaya, Delia ;

Rodrigo-Torres, Daniel ;

Graupera, Isabel ;

Aguilar-Bravo, Beatriz ;

Chesne, Christophe ;

Najimi, Mustapha ;

Sokal, Etienne ;

Jose Lozano, Juan ;

van Grunsven, Leo A. ;

Verfaillie, Catherine M. ;

Sancho-Bru, Pau .

CELL STEM CELL, 2018, 23 (01) :101-+

[16] Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression [J].

Corciulo, Carmen ;

Lendhey, Matin ;

Wilder, Tuere ;

Schoen, Hanna ;

Cornelissen, Alexander Samuel ;

Chang, Gregory ;

Kennedy, Oran D. ;

Cronstein, Bruce N. .

NATURE COMMUNICATIONS, 2017, 8

[17] De novo neo-hyaline-cartilage from bovine organoids in viscoelastic hydrogels [J].

Crispim, Joao F. ;

Ito, Keita .

ACTA BIOMATERIALIA, 2021, 128 :236-249

[18] Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin [J].

de lageneste, Oriane Duchamp ;

Julien, Anais ;

Abou-Khalil, Rana ;

Frangi, Giulia ;

Carvalho, Caroline ;

Cagnard, Nicolas ;

Cordier, Corinne ;

Conway, Simon J. ;

Colnot, Celine .

NATURE COMMUNICATIONS, 2018, 9

[19] Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells [J].

Diekman, Brian O. ;

Christoforou, Nicolas ;

Willard, Vincent P. ;

Sun, Haosi ;

Sanchez-Adams, Johannah ;

Leong, Kam W. ;

Guilak, Farshid .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (47) :19172-19177

[20] Self-organizing optic-cup morphogenesis in three-dimensional culture [J].

Eiraku, Mototsugu ;

Takata, Nozomu ;

Ishibashi, Hiroki ;

Kawada, Masako ;

Sakakura, Eriko ;

Okuda, Satoru ;

Sekiguchi, Kiyotoshi ;

Adachi, Taiji ;

Sasai, Yoshiki .

NATURE, 2011, 472 (7341) :51-U73

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