Cartilage organoids and osteoarthritis research: a narrative review

被引:12
作者
Zeng, Daofu [1 ,2 ]
Chen, Yeping [2 ]
Liao, Zhidong [1 ]
Wei, Guizheng [2 ]
Huang, Xiajie [1 ]
Liang, Rongyuan [2 ]
Lu, William W. [3 ]
Yi, Dan [4 ,5 ]
Chen, Yan [1 ,2 ]
机构
[1] Guangxi Med Univ, Collaborat Innovat Ctr Regenerat Med & Med BioReso, Nanning, Guangxi, Peoples R China
[2] Guangxi Med Univ, Dept Bone & Joint Surg, Affiliated Hosp 1, Nanning, Guangxi, Peoples R China
[3] Univ Hong Kong, Dept Orthoped & Traumatol, Pokfulam, Hong Kong, Peoples R China
[4] Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp Aided Drug Discovery, Shenzhen, Peoples R China
[5] Chinese Acad Sci, Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
organoids; cartilage organoids; osteoarthritis; disease model; regeneration and repair; PLURIPOTENT STEM-CELLS; IN-VITRO; MODELING DEVELOPMENT; TISSUE; DIFFERENTIATION; GENERATION; MATRIGEL; THERAPY; LIVER; KNEE;
D O I
10.3389/fbioe.2023.1278692
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Osteoarthritis (OA) is one of the most common degenerative joint diseases, significantly impacting individuals and society. With the acceleration of global aging, the incidence of OA is increasing. The pathogenesis of osteoarthritis is not fully understood, and there is no effective way to alleviate the progression of osteoarthritis. Therefore, it is necessary to develop new disease models and seek new treatments for OA. Cartilage organoids are three-dimensional tissue masses that can simulate organ structure and physiological function and play an important role in disease modeling, drug screening, and regenerative medicine. This review will briefly analyze the research progress of OA, focusing on the construction and current development of cartilage organoids, and then describe the application of cartilage organoids in OA modeling, drug screening, and regeneration and repair of cartilage and bone defects. Finally, some challenges and prospects in the development of cartilaginous organoids are discussed.
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页数:11
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